Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | BUB1 | O43683 | 1/20 | 0.37 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.36 |
| ▸ | TUBB | P07437 | 1/20 | 0.36 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.36 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.36 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.36 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.36 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.36 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.36 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.36 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.36 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.36 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.36 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.36 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.36 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4334975 | 0.83 | MAPT (0.45) | KDM4EMEN1KMT2AMAPTHSD17B10 | |
| SCHEMBL4338517 | 0.83 | BUB1 (0.41) | POLBBUB1KDM4EMEN1KMT2A | |
| SCHEMBL4347024 | 0.83 | KDM4E (0.47) | KDM4EMEN1KMT2AMAPTALOX5 | |
| SCHEMBL4337467 | 0.77 | MCL1 (0.41) | BUB1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL4339512 | 0.73 | MAPK14 (0.36) | BUB1KDM4EMEN1KMT2AMAPT | |
| SCHEMBL4343913 | 0.73 | KMT2A (0.43) | POLBKDM4EMEN1KMT2AMAPT | |
| SCHEMBL4342779 | 0.71 | MAPKAPK2 (0.37) | BUB1MAPKAPK2GSK3B | |
| SCHEMBL4346788 | 0.71 | MMP2 (0.41) | POLBBUB1KDM4EMEN1KMT2A | |
| SCHEMBL4332758 | 0.71 | MEN1 (0.57) | POLBBUB1KDM4EMEN1KMT2A | |
| Potassium SCHEMBL4334708 | 0.70 | MEN1 (0.56) | POLBBUB1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501797-B1 | 3-(SUBSTITUTED AMINO)-1H-INDOLE-2-CARBOXYLIC ACID ESTER AND 3-(SUBSTITUTED AMINO)-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID ESTER DERIVATIVES AS INTERLEUKIN-4 GENE EXPRESSION INHIBITORS | AVENTIS PHARMA INC (US) | 2009-08-05 | — | — | EP | claimed |