Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 2/20 | 0.46 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4323296 | 0.94 | ALDH1A1 (0.52) | HTTALDH1A1SMN1; SMN2PARP1PIK3CG | |
| SCHEMBL4329589 | 0.89 | PIK3CG (0.45) | HTTALDH1A1SMN1; SMN2PIK3CGCYP11B1 | |
| SCHEMBL4324337 | 0.85 | PIK3CG (0.41) | ALDH1A1SMN1; SMN2PIK3CGCYP11B1CYP11B2 | |
| SCHEMBL4342336 | 0.83 | CYP11B2 (0.46) | ALDH1A1SMN1; SMN2PIK3CGCYP11B1CYP11B2 | |
| SCHEMBL8231100 | 0.83 | PIK3CG (0.46) | ALDH1A1SMN1; SMN2PIK3CGCYP11B1CYP11B2 | |
| SCHEMBL4334126 | 0.81 | PIK3CG (0.45) | ALDH1A1SMN1; SMN2PIK3CGCYP11B1CYP11B2 | |
| SCHEMBL4324289 | 0.81 | PIK3CG (0.47) | PARP1PIK3CGCYP11B1CYP11B2CYP1A2 | |
| SCHEMBL2027087 | 0.80 | DHPS (0.55) | ALDH1A1SMN1; SMN2PARP1PIK3CGCYP11B1 | |
| SCHEMBL4331807 | 0.80 | PIK3CG (0.58) | PIK3CGCYP11B1CYP11B2CYP1A2CYP17A1 | |
| SCHEMBL2019134 | 0.80 | PIK3CG (0.47) | PIK3CGCYP11B1CYP11B2CYP1A2CYP17A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090149505-A1 | Metabotropic Glutamate Receptor-Potentiating Isoindolones | ASTRAZENECA AB (SE) | 2009-06-11 | — | — | US | claimed |
| EP-1986998-A1 | METABOTROPIC GLUTAMATE RECEPTOR-POTENTIATING SOINDOLONES | AstraZeneca AB (SE) | 2008-11-05 | — | — | EP | claimed |
| WO-2007095024-A1 | METABOTROPIC GLUTAMATE RECEPTOR-POTENTIATING ΓSOINDOLONES | ASTRAZENECA AB (SE) | 2007-08-23 | — | — | WO | claimed |
| US-20090149505-A1 | Metabotropic Glutamate Receptor-Potentiating Isoindolones | ASTRAZENECA AB (SE) | 2009-06-11 | — | — | US | disclosed |
| US-20090149505-A1 | Metabotropic Glutamate Receptor-Potentiating Isoindolones | ASTRAZENECA AB (SE) | 2009-06-11 | — | — | US | disclosed |
| US-20090149505-A1 | Metabotropic Glutamate Receptor-Potentiating Isoindolones | ASTRAZENECA AB (SE) | 2009-06-11 | — | — | US | disclosed |
| WO-2007095024-A1 | METABOTROPIC GLUTAMATE RECEPTOR-POTENTIATING ΓSOINDOLONES | ASTRAZENECA AB (SE) | 2007-08-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090149505-A1 | Metabotropic Glutamate Receptor-Potentiating Isoindolones | GRM1, GRIN1, GRM3 | HTT 1498/4885ALDH1A1 2048/4885SMN1; SMN2 2253/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.