Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 3/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.36 |
| ▸ | GCGR | P47871 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.35 |
| ▸ | EIF2AK3 | Q9NZJ5 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 2/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | BUB1 | O43683 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4343913 | 0.92 | KMT2A (0.43) | ALOX5KMT2AALDH1A1MEN1HSD17B10 | |
| SCHEMBL4341686 | 0.88 | ALOX15 (0.43) | GCGRALOX15MAPT | |
| SCHEMBL4333018 | 0.87 | KIF11 (0.43) | ALDH1A1MAPTNPSR1 | |
| SCHEMBL4346788 | 0.85 | MMP2 (0.41) | ALOX5CDK2IMPDH2KMT2AALDH1A1 | |
| SCHEMBL4347024 | 0.85 | KDM4E (0.47) | ALOX5KMT2AALDH1A1MEN1HSD17B10 | |
| SCHEMBL4334687 | 0.83 | CYP1A2 (0.43) | KMT2AALDH1A1MEN1HSD17B10LMNA | |
| SCHEMBL4351602 | 0.81 | GAA (0.44) | ALOX5GCGRKMT2AALDH1A1MEN1 | |
| SCHEMBL4343923 | 0.77 | ALDH1A1 (0.40) | MAPK14BRAFEIF2AK3CDK2MAP4K4 | |
| SCHEMBL4344098 | 0.76 | NAMPT (0.39) | ALOX5BRAFEIF2AK3MAP4K4ALDH1A1 | |
| SCHEMBL4340304 | 0.74 | KMT2A (0.58) | KMT2AALDH1A1MEN1HSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501797-B1 | 3-(SUBSTITUTED AMINO)-1H-INDOLE-2-CARBOXYLIC ACID ESTER AND 3-(SUBSTITUTED AMINO)-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID ESTER DERIVATIVES AS INTERLEUKIN-4 GENE EXPRESSION INHIBITORS | AVENTIS PHARMA INC (US) | 2009-08-05 | — | — | EP | claimed |