Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | KIF11 | P52732 | 4/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28280335 | 0.76 | BACE1 (0.32) | BACE1KIF11 | |
| SCHEMBL5318029 | 0.73 | BACE1 (0.36) | BACE1KIF11KDM4E | |
| SCHEMBL887176 | 0.70 | POLB (0.42) | — | |
| SCHEMBL3515583 | 0.70 | LMNA (0.35) | KIF11 | |
| SCHEMBL3515586 | 0.70 | LMNA (0.35) | KIF11 | |
| SCHEMBL23648799 | 0.70 | PDE3A (0.36) | KIF11 | |
| SCHEMBL3789736 | 0.69 | NT5E (0.31) | KIF11 | |
| SCHEMBL5150771 | 0.69 | NT5E (0.51) | — | |
| SCHEMBL5201335 | 0.68 | TYMP (0.42) | BACE1 | |
| SCHEMBL1739169 | 0.68 | PDE3A (0.32) | KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1677822-A4 | 4'-THIONUCLEOSIDES AND OLIGOMERIC COMPOUNDS | ISIS PHARMACEUTICALS INC (US) | 2009-08-19 | — | — | EP | disclosed |
| EP-1677822-A2 | 4'-THIONUCLEOSIDES AND OLIGOMERIC COMPOUNDS | ISIS PHARMACEUTICALS, INC. (US) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005027962-A1 | 4’-THIONUCLEOSIDES AND OLIGOMERIC COMPOUNDS | ISIS PHARMACEUTICALS, INC. (US) | 2005-03-31 | — | — | WO | disclosed |