Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 15/20 | 0.83 |
| ▸ | MAOB | P27338 | 15/20 | 0.83 |
| ▸ | ESR1 | P03372 | 2/20 | 0.78 |
| ▸ | PGR | P06401 | 2/20 | 0.78 |
| ▸ | HTR1A | P08908 | 2/20 | 0.78 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.78 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.78 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.78 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.78 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.78 |
| ▸ | DRD1 | P21728 | 1/20 | 0.78 |
| ▸ | DRD3 | P35462 | 1/20 | 0.78 |
| ▸ | GSK3B | P49841 | 1/20 | 0.76 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.62 |
| ▸ | PRKCG | P05129 | 2/20 | 0.62 |
| ▸ | PRKCB | P05771 | 2/20 | 0.62 |
| ▸ | PRKCA | P17252 | 2/20 | 0.62 |
| ▸ | PRKCH | P24723 | 2/20 | 0.62 |
| ▸ | PRKCI | P41743 | 2/20 | 0.62 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL1650306 | 0.94 | MAOA (0.74) | MAOAMAOBESR1PGRHTR1A | |
| SCHEMBL11071680 | 0.90 | MAOA (0.68) | MAOAMAOBESR1PGRHTR1A | |
| SCHEMBL11067781 | 0.90 | GSK3B (0.74) | MAOAMAOBESR1PGRHTR1A | |
| SCHEMBL14424694 | 0.90 | ESR1 (0.68) | MAOAMAOBESR1PGRHTR1A | |
| SCHEMBL14424683 | 0.89 | MAOA (0.67) | MAOAMAOBESR1PGRHTR1A | |
| Tafenoquine SCHEMBL347388 | 0.88 | ESR1 (1.00) | MAOAMAOBESR1PGRHTR1A | |
| Tafenoquine SCHEMBL29575330 | 0.88 | ESR1 (1.00) | MAOAMAOBESR1PGRHTR1A | |
| Tafenoquine SCHEMBL31160547 | 0.88 | ESR1 (1.00) | MAOAMAOBESR1PGRHTR1A | |
| Tafenoquine SCHEMBL29450724 | 0.88 | ESR1 (1.00) | MAOAMAOBESR1PGRHTR1A | |
| Tafenoquine SCHEMBL5426820 | 0.87 | ESR1 (0.98) | MAOAMAOBESR1PGRHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4431807-A | PARASITICIDES; MALARIA; TISSUE AND BLOOD DISORDERS | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 1984-02-14 | — | — | US | claimed |
| US-8809368-B2 | Compounds affecting gap junction activity | KANSAS STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2014-08-19 | — | — | US | disclosed |
| US-20090143425-A1 | COMPOUNDS AFFECTING GAP JUNCTION ACTIVITY | KANSAS STATE UNIVERSITY RESEARCH FOUNDATION (US) | 2009-06-04 | — | — | US | disclosed |
| US-20070179123-A1 | Methods and compositions for treating diseases associated with pathogenic proteins | CHIANG PETER K | 2007-08-02 | — | — | US | disclosed |
| US-20070179123-A1 | Methods and compositions for treating diseases associated with pathogenic proteins | CHIANG PETER K | 2007-08-02 | — | — | US | disclosed |
| US-4431807-A | PARASITICIDES; MALARIA; TISSUE AND BLOOD DISORDERS | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY (US) | 1984-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090143425-A1 | COMPOUNDS AFFECTING GAP JUNCTION ACTIVITY | GJB2, GJA1, GAP43 | MAOA 3264/4885MAOB 2839/4885ESR1 4138/4885 |
| US-20070179123-A1 | Methods and compositions for treating diseases associated with pathogenic proteins | PRNP, APP, PSEN1 | MAOA 1666/4885MAOB 1689/4885ESR1 1817/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.