Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 3/20 | 0.32 |
| ▸ | HTR2B | P41595 | 3/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 3/20 | 0.31 |
| ▸ | HTR2A | P28223 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | MPO | P05164 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4357196 | 0.85 | SLC6A4 (0.36) | HTR6ALDH1A1TAAR1HTR2CHTR2B | |
| SCHEMBL13718456 | 0.85 | ALDH1A1 (0.39) | HTR6ALDH1A1TDP1TAAR1NPSR1 | |
| SCHEMBL16018751 | 0.80 | HTR6 (0.38) | HTR6ALDH1A1TDP1TAAR1NPSR1 | |
| SCHEMBL1020357 | 0.71 | SMN1; SMN2 (0.39) | HTR6ALDH1A1TDP1NPSR1HTR2C | |
| SCHEMBL8203524 | 0.71 | ALDH1A1 (0.41) | HTR6ALDH1A1TDP1TAAR1NPSR1 | |
| SCHEMBL1021489 | 0.70 | ALDH1A1 (0.36) | HTR6ALDH1A1LOXL2TDP1HTR2C | |
| SCHEMBL1020748 | 0.70 | HTR6 (0.36) | HTR6ALDH1A1TDP1NPSR1HTR2C | |
| SCHEMBL1021374 | 0.70 | ALDH1A1 (0.37) | HTR6ALDH1A1LOXL2TDP1TAAR1 | |
| SCHEMBL1019826 | 0.70 | ALDH1A1 (0.37) | HTR6ALDH1A1HTR2CMAOB | |
| SCHEMBL16016397 | 0.69 | HTR6 (0.39) | HTR6ALDH1A1TDP1TAAR1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094677-A1 | THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURO-DEGENERATIVE DISEASES | NV Remynd (BE) | 2009-09-02 | — | — | EP | claimed |
| WO-2008061781-A1 | THIADIAZOLE DERIVATIVES FOR THE TREATMENT OF NEURO-DEGENERATIVE DISEASES | NV REMYND (BE) | 2008-05-29 | — | — | WO | claimed |