SCHEMBL434770

SCHEMBL434770

CO/N=C(/COc1ccc(COc2ccc(CCC(=O)OC)cc2)cc1)c1ccccc1

nearest known ligand 0.64

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 9/20 0.64
FFAR4 Q5NUL3 2/20 0.51
GAA P10253 2/20 0.46
MEN1 O00255 1/20 0.46
KMT2A Q03164 1/20 0.46
ALDH1A1 P00352 2/20 0.45
HTT P42858 2/20 0.45
SMN1; SMN2 Q16637 2/20 0.45
L3MBTL1 Q9Y468 1/20 0.45
PLA2G4B P0C869 1/20 0.44
MAPT P10636 1/20 0.44
RAB9A P51151 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15239468 1.00 FFAR1 (0.64) FFAR1FFAR4GAAMEN1KMT2A
SCHEMBL434771 1.00 FFAR1 (0.64) FFAR1FFAR4GAAMEN1KMT2A
SCHEMBL437124 0.91 FFAR1 (0.70) FFAR1FFAR4
SCHEMBL22668032 0.91 FFAR1 (0.70) FFAR1FFAR4
SCHEMBL437123 0.91 FFAR1 (0.70) FFAR1FFAR4
SCHEMBL435107 0.89 FFAR1 (0.64) FFAR1FFAR4GAAALDH1A1HTT
SCHEMBL435106 0.89 FFAR1 (0.64) FFAR1FFAR4GAAALDH1A1HTT
SCHEMBL15248956 0.89 FFAR1 (0.64) FFAR1FFAR4GAAALDH1A1HTT
SCHEMBL10262172 0.89 FFAR1 (0.67) FFAR1GAAMEN1KMT2AALDH1A1
SCHEMBL434604 0.88 FFAR1 (0.63) FFAR1FFAR4GAAMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2595952-B1 AGONISTS OF GPR40 CONNEXIOS LIFE SCIENCES PVT LTD (IN) 2020-11-18 EP disclosed
US-9278915-B2 Agonists of GPR40 CONNEXIOS LIFE SCIENCES PVT LTD (IN) 2016-03-08 US disclosed
US-20130237571-A1 AGONISTS OF GPR40 Conexios Life Sciences PVT. LTD. (IN) 2013-09-12 US disclosed
EP-2595952-A1 AGONISTS OF GPR40 Connexios Life Sciences Pvt. Ltd. (IN) 2013-05-29 EP disclosed
WO-2012011125-A1 AGONISTS OF GPR40 CONNEXIOS LIFE SCIENCES PVT. LTD. (IN) 2012-01-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130237571-A1 AGONISTS OF GPR40 GPR65, GPR55, GPR68 FFAR1 24/4885FFAR4 26/4885GAA 1970/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.