Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.69 |
| ▸ | MEN1 | O00255 | 4/20 | 0.69 |
| ▸ | CES2 | O00748 | 1/20 | 0.66 |
| ▸ | CES1 | P23141 | 1/20 | 0.66 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | BLM | P54132 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.62 |
| ▸ | TSHR | P16473 | 2/20 | 0.62 |
| ▸ | NPC1 | O15118 | 3/20 | 0.60 |
| ▸ | RAB9A | P51151 | 3/20 | 0.60 |
| ▸ | THRA | P10827 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11060904 | 0.86 | KMT2A (0.73) | KMT2AMEN1CES2CES1TP53 | |
| SCHEMBL29508878 | 0.84 | KMT2A (0.71) | KMT2AMEN1CES2CES1TP53 | |
| SCHEMBL297043 | 0.84 | KMT2A (0.71) | KMT2AMEN1CES2CES1TP53 | |
| SCHEMBL13168473 | 0.83 | KMT2A (0.69) | KMT2AMEN1CES2CES1TP53 | |
| SCHEMBL10355 | 0.83 | KMT2A (0.69) | KMT2AMEN1CES2CES1TP53 | |
| Hydrochloric Acid SCHEMBL2045145 | 0.83 | KMT2A (0.69) | KMT2AMEN1CES2CES1TP53 | |
| SCHEMBL6959553 | 0.83 | KMT2A (0.69) | KMT2AMEN1CES2CES1TP53 | |
| SCHEMBL432613 | 0.83 | KMT2A (0.69) | KMT2AMEN1CES2CES1TP53 | |
| SCHEMBL4494074 | 0.83 | KMT2A (0.69) | KMT2AMEN1CES2CES1TP53 | |
| SCHEMBL29282736 | 0.83 | KMT2A (0.69) | KMT2AMEN1CES2CES1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3654958-A1 | METHODS OF PATIENT SELECTION AND TREATING TRXR- OR PRDX-OVEREXPRESSED CANCERS | Triact Therapeutics, Inc. (US) | 2020-05-27 | — | — | EP | disclosed |
| WO-2018237344-A1 | METHODS OF PATIENT SELECTION AND TREATING TRXR- OR PRDX-OVEREXPRESSED CANCERS | TRIACT THERAPEUTICS, INC. (US) | 2018-12-27 | — | — | WO | disclosed |
| CN-103169973-A | Treatment of breast cancer with iodonitrobenzamides in combination with anti-tumor agents | BIPAR SCIENCES INC | 2013-06-26 | — | — | CN | disclosed |
| EP-2595619-A1 | METHODS OF TREATING METASTATIC BREAST CANCER WITH 4-IODO-3-NITROBENZAMIDE AND IRINOTECAN | BiPar Sciences, Inc. (US) | 2013-05-29 | — | — | EP | disclosed |
| WO-2012012454-A1 | METHODS OF TREATING METASTATIC BREAST CANCER WITH 4-IODO-3-NITROBENZAMIDE AND IRINOTECAN | BIPAR SCIENCES, INC. (US) | 2012-01-26 | — | — | WO | disclosed |
| EP-2059498-A2 | TREATMENT OF CANCER | Bipar Sciences, Inc. (US) | 2009-05-20 | — | — | EP | disclosed |
| WO-2008030883-A2 | TREATMENT OF CANCER | BIPAR SCIENCES, INC. (US) | 2008-03-13 | — | — | WO | disclosed |