Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13563348 | 0.85 | HTT (0.55) | HTTMAPTALDH1A1LMNAKMT2A | |
| SCHEMBL10032057 | 0.67 | HSD17B10 (0.63) | HTTMAPTKDM4EHSD17B10HPGD | |
| SCHEMBL29431542 | 0.65 | PARP1 (0.82) | MAPTKDM4EALDH1A1LMNAKMT2A | |
| SCHEMBL5794718 | 0.65 | PARP1 (0.82) | MAPTKDM4EALDH1A1LMNAKMT2A | |
| SCHEMBL21777592 | 0.65 | RAB9A (0.76) | MAPTKDM4EHSD17B10HPGDTSHR | |
| SCHEMBL30176850 | 0.65 | TNKS2 (1.00) | MAPTKDM4EALDH1A1LMNAKMT2A | |
| SCHEMBL3826724 | 0.65 | TNKS2 (1.00) | MAPTKDM4EALDH1A1LMNAKMT2A | |
| SCHEMBL14266777 | 0.65 | TNKS2 (0.69) | MAPTKDM4EHPGDALDH1A1LMNA | |
| SCHEMBL22639721 | 0.62 | NPC1 (0.62) | HTTMAPTKDM4EHSD17B10HPGD | |
| SCHEMBL16404338 | 0.62 | PDE10A (0.84) | MAPTKDM4ELMNAKMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090275586-A1 | HETEROCYCLIC INHIBITORS OF PDE4 | KALYPSYS, INC. (US) | 2009-11-05 | — | — | US | disclosed |
| WO-2008045664-A2 | HETEROCYCLIC PDE4 INHIBITORS AS ANTIINFLAMMATORY AGENTS | KALYPSYS, INC. (US) | 2008-04-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090275586-A1 | HETEROCYCLIC INHIBITORS OF PDE4 | PDE4A, PDE4B, PDE4C | HTT 2759/4885MAPT 4062/4885KDM4E 524/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.