Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 6/20 | 0.82 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.76 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.69 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.68 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | PARP3 | Q9Y6F1 | 2/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29431542 | 1.00 | PARP1 (0.82) | PARP1TNKS2PDE10APARP2KDM4C | |
| SCHEMBL29900512 | 0.90 | PARP1 (1.00) | PARP1TNKS2PDE10APARP2KMT2A | |
| SCHEMBL168776 | 0.90 | PARP1 (1.00) | PARP1TNKS2PDE10APARP2KMT2A | |
| SCHEMBL16404338 | 0.90 | PDE10A (0.84) | PARP1TNKS2PDE10APARP2KMT2A | |
| SCHEMBL1586541 | 0.89 | PARP1 (0.91) | PARP1TNKS2PDE10APARP2KMT2A | |
| SCHEMBL30176861 | 0.88 | PARP1 (0.89) | PARP1TNKS2PDE10APARP2KMT2A | |
| SCHEMBL22857122 | 0.88 | PARP1 (0.89) | PARP1TNKS2PDE10APARP2KMT2A | |
| SCHEMBL30176973 | 0.88 | PARP1 (0.89) | PARP1TNKS2PDE10APARP2KMT2A | |
| SCHEMBL14621928 | 0.88 | PARP1 (0.89) | PARP1TNKS2PDE10APARP2KMT2A | |
| SCHEMBL28598382 | 0.88 | PARP1 (0.89) | PARP1TNKS2PDE10APARP2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12018003-B2 | Substituted pyrimidines as matrix metalloproteinase-9 hemopexin domain inhibitors | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2024-06-25 | — | — | US | disclosed |
| CN-115010671-B | One-step synthesis method of 2-substituted quinazolinone | 江苏大学 | 2023-10-10 | — | — | CN | disclosed |
| CN-112174899-B | Application of light-promoted Minisci C-H alkylation reaction in preparation of alkyl-substituted azacycle | 南开大学 | 2023-01-17 | — | — | CN | disclosed |
| CN-112645887-B | Preparation method of quinazolinone derivative | 淮阴工学院（CN） | 2023-01-13 | — | — | CN | disclosed |
| CN-115010671-A | One-step synthesis method of 2-substituted quinazolinone | 江苏大学 | 2022-09-06 | — | — | CN | disclosed |
| CN-109384731-B | Method for preparing quinazolinone from enol | 南京理工大学 | 2021-10-08 | — | — | CN | disclosed |
| CN-112645887-A | Preparation method of quinazolinone derivative | 淮阴工学院 | 2021-04-13 | — | — | CN | disclosed |
| CN-112174899-A | Application of light-promoted Minisci C-H alkylation reaction in preparation of alkyl-substituted azacycle | 南开大学 | 2021-01-05 | — | — | CN | disclosed |
| CN-107778256-B | Method for synthesizing quinazolinone from anthranilamide and unsaturated aldehyde | 南京理工大学 | 2020-06-19 | — | — | CN | disclosed |
| CN-106518789-B | A method of synthesis Quinazol derivative | 南京理工大学 | 2019-04-16 | — | — | CN | disclosed |
| US-5444042-A | Administering peptide ketoamides, peptide ketoacids, and peptide ketoesters | CORTEX PHARMACEUTICALS (US) | 1995-08-22 | — | — | US | disclosed |
| EP-0650368-A1 | USE OF CALPAIN INHIBITORS IN THE INHIBITION AND TREATMENT OF MEDICAL CONDITIONS ASSOCIATED WITH INCREASED CALPAIN ACTIVITY | CORTEX PHARMACEUTICALS, INC. (US) | 1995-05-03 | — | — | EP | disclosed |
| WO-1994021259-A1 | QUINAZOLINONES SUBSTITUTED WITH PHENOXYPHENYLACETIC ACID DERIVATIVES | MERCK & CO., INC. (US) | 1994-09-29 | — | — | WO | disclosed |
| US-5304565-A | Angiotensin II antagonists | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-04-19 | — | — | US | disclosed |
| WO-1994000095-A2 | USE OF CALPAIN INHIBITORS IN THE INHIBITION AND TREATMENT OF MEDICAL CONDITIONS ASSOCIATED WITH INCREASED CALPAIN ACTIVITY | CORTEX PHARMACEUTICALS, INC. (US) | 1994-01-06 | — | — | WO | disclosed |
| WO-1992011850-A2 | USE OF CALPAIN INHIBITORS IN THE INHIBITION AND TREATMENT OF NEURODEGENERATION | CORTEX PHARMACEUTICALS, INC. (US) | 1992-07-23 | — | — | WO | disclosed |
| EP-0445811-A2 | Nitrogen-containing heterocyclic compounds, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1991-09-11 | — | — | EP | disclosed |
| US-4847202-A | Heterocyclic inhibitors of serine proteases | GEORGIA TECH RESEARCH INSTITUTE (US) | 1989-07-11 | — | — | US | disclosed |
| US-4678781-A | BACTERICIDAL ANTIBIOTICS | ICI PHARMA (FR) | 1987-07-07 | — | — | US | disclosed |
| US-4585793-A | Thioester inhibitors of serine proteases | GEORGIA TECH RESEARCH INSTITUTE (US) | 1986-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12018003-B2 | Substituted pyrimidines as matrix metalloproteinase-9 hemopexin domain inhibitors | MMP9, MMP7, MMP11 | PARP1 416/4885TNKS2 290/4885PDE10A 4085/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.