Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | ALKBH2 | Q6NS38 | 3/20 | 0.36 |
| ▸ | FTO | Q9C0B1 | 3/20 | 0.36 |
| ▸ | ALKBH3 | Q96Q83 | 2/20 | 0.36 |
| ▸ | ICMT | O60725 | 2/20 | 0.35 |
| ▸ | ALKBH5 | Q6P6C2 | 2/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.34 |
| ▸ | BCL2 | P10415 | 1/20 | 0.34 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4037157 | 0.84 | ICMT (0.41) | ICMTIRAK4HDAC1HDAC8HDAC6 | |
| SCHEMBL3595139 | 0.74 | PTGER1 (0.41) | PTGS2KMT2AICMT | |
| SCHEMBL3594920 | 0.72 | PTGER1 (0.41) | PTGS2ICMTIRAK4MAPTHDAC1 | |
| SCHEMBL3587219 | 0.71 | ALDH1A1 (0.44) | KDM4EPOLBMAPT | |
| SCHEMBL4035309 | 0.67 | ICMT (0.51) | KDM4EMEN1KMT2AICMTMAPT | |
| SCHEMBL4354618 | 0.65 | KDM4E (0.36) | PTGS2KDM4EKMT2AHDAC1HDAC8 | |
| SCHEMBL10204165 | 0.63 | PTGS2 (0.56) | PTGS2PTGS1POLBMEN1KMT2A | |
| SCHEMBL4350902 | 0.62 | ALDH1A1 (0.43) | KDM4EKMT2A | |
| SCHEMBL4038440 | 0.62 | NR4A2 (0.49) | KDM4EGAAMEN1KMT2AICMT | |
| SCHEMBL4354642 | 0.61 | ICMT (0.56) | ICMTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090281152-A1 | Indole Compounds Having Affinity to the EP1 Receptor | GLAXO GROUP LIMITED (GB) | 2009-11-12 | — | — | US | disclosed |
| US-20090281152-A1 | Indole Compounds Having Affinity to the EP1 Receptor | GLAXO GROUP LIMITED (GB) | 2009-11-12 | — | — | US | disclosed |
| US-20090281152-A1 | Indole Compounds Having Affinity to the EP1 Receptor | GLAXO GROUP LIMITED (GB) | 2009-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090281152-A1 | Indole Compounds Having Affinity to the EP1 Receptor | PTGER1, PTGER2, PTGER3 | PTGS2 132/4885PTGS1 25/4885KDM4E 2597/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.