Sugi Predict

Sugi Predict / Compounds / SCHEMBL434895

SCHEMBL434895

SCHEMBL434895

C=CCCCOC(=O)CNC(=O)C(=O)OC

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TET2 Q6N021 1/20 0.53
▸ ALDH1A1 P00352 4/20 0.47
▸ LMNA P02545 2/20 0.47
▸ EGLN1 Q9GZT9 2/20 0.44
▸ TDP1 Q9NUW8 1/20 0.37
▸ POLB P06746 1/20 0.37
▸ MEN1 O00255 2/20 0.36
▸ KMT2A Q03164 2/20 0.36
▸ GAA P10253 1/20 0.36
▸ L3MBTL1 Q9Y468 1/20 0.36
▸ MAPT P10636 3/20 0.33
▸ USP2 O75604 2/20 0.33
▸ CYP3A4 P08684 2/20 0.33
▸ SMN1; SMN2 Q16637 2/20 0.33
▸ RECQL P46063 1/20 0.33
▸ ABCC4 O15439 1/20 0.33
▸ LPAR2 Q9HBW0 1/20 0.33
▸ LPAR3 Q9UBY5 1/20 0.33
▸ FAAH O00519 1/20 0.33
▸ HPGD P15428 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL433341 0.88 EGLN1 (0.50) TET2ALDH1A1LMNAEGLN1TDP1
SCHEMBL10029159 0.83 TET2 (0.51) TET2ALDH1A1EGLN1TDP1POLB
SCHEMBL26247715 0.78 ALDH1A1 (0.50) ALDH1A1LMNATDP1POLBL3MBTL1
SCHEMBL434612 0.77 CA12 (0.43) ALDH1A1LMNATDP1POLBMEN1
SCHEMBL8220165 0.76 GAA (0.47) ALDH1A1LMNAGAA
SCHEMBL18039340 0.76 TET2 (0.69) TET2ALDH1A1EGLN1GAAMAPT
SCHEMBL9358833 0.75 ALDH1A1 (0.48) ALDH1A1LMNAGAAL3MBTL1MAPT
SCHEMBL22492477 0.74 ALDH1A1 (0.46) ALDH1A1LMNATDP1POLBGAA
SCHEMBL26247997 0.73 ALDH1A1 (0.53) ALDH1A1LMNAL3MBTL1MAPTUSP2
SCHEMBL3445881 0.73 ALDH1A1 (0.47) ALDH1A1LMNAGAAL3MBTL1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2595994-B1 PROCESS FOR PREPARING PYRANO - [2,3-C]PYRIDINE DERIVATIVES GLAXO GROUP LTD (GB) 2016-04-20 — — EP disclosed
US-8759523-B2 Process for preparing pyrano—[2,3-C]pyridine derivatives GLAXO GROUP LIMITED (GB) 2014-06-24 — — US disclosed
US-8759523-B2 Process for preparing pyrano—[2,3-C]pyridine derivatives GLAXO GROUP LIMITED (GB) 2014-06-24 — — US disclosed
EP-2595994-A2 PROCESS FOR PREPARING PYRANO - [2,3-C]PYRIDINE DERIVATIVES Glaxo Group Limited (GB) 2013-05-29 — — EP disclosed
US-20130116436-A1 PROCESS FOR PREPARING PYRANO - [2,3-C]PYRIDINE DERIVITAVES GLAXO GROUP LIMITED (GB) 2013-05-09 — — US disclosed
US-20130116436-A1 PROCESS FOR PREPARING PYRANO - [2,3-C]PYRIDINE DERIVITAVES GLAXO GROUP LIMITED (GB) 2013-05-09 — — US disclosed
WO-2012012391-A2 PROCESS FOR PREPARING PYRANO - [2,3-C]PYRIDINE DERIVATIVES GLAXO GROUP LIMITED (GB) 2012-01-26 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130116436-A1 PROCESS FOR PREPARING PYRANO - [2,3-C]PYRIDINE DERIVITAVES DHPS, AKR1C3, Q6ZSR9 TET2 445/4885ALDH1A1 186/4885LMNA 2537/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.