Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 1/20 | 0.63 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.59 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.54 |
| ▸ | BAZ1A | Q9NRL2 | 1/20 | 0.53 |
| ▸ | CA12 | O43570 | 4/20 | 0.53 |
| ▸ | CA1 | P00915 | 4/20 | 0.53 |
| ▸ | CA2 | P00918 | 4/20 | 0.53 |
| ▸ | CA9 | Q16790 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.52 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.52 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.51 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.50 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.50 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.50 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3671992 | 0.86 | CHRNA7 (0.72) | CHRNA7MEN1KMT2AMAPTNTRK1 | |
| SCHEMBL4348490 | 0.86 | GRIK1 (0.59) | GRIK1EPHX2CA12CA1CA2 | |
| SCHEMBL4348880 | 0.84 | EPHX2 (0.69) | GRIK1EPHX2CHRNA7BAZ1ACA12 | |
| SCHEMBL6229028 | 0.84 | MTOR (0.56) | GRIK1CHRNA7MEN1KMT2AMAPT | |
| SCHEMBL4354217 | 0.84 | MAPT (0.53) | GRIK1MEN1KMT2AMAPTHTT | |
| SCHEMBL4354666 | 0.83 | EPHX2 (0.62) | EPHX2MEN1KMT2AMAPTHTT | |
| SCHEMBL4356017 | 0.83 | GRIK1 (0.56) | GRIK1EPHX2CHRNA7BAZ1ACA12 | |
| SCHEMBL4351128 | 0.82 | EPHX2 (0.61) | GRIK1EPHX2BAZ1ACA12CA1 | |
| SCHEMBL4346945 | 0.82 | NTRK1 (0.74) | GRIK1EPHX2CHRNA7BAZ1ACA12 | |
| SCHEMBL4350084 | 0.82 | MTOR (0.56) | GRIK1EPHX2CHRNA7MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110065760-A1 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES AND USE THEREOF | JERINI AG (DE) | 2011-03-17 | — | — | US | claimed |
| EP-2100876-A2 | New compounds for the inhibition of rotamases and use thereof | Jerini AG (DE) | 2009-09-16 | — | — | EP | claimed |
| US-20070054904-A1 | Phenol derivatives and their use as rotamase inhibitors | JERINI AG (DE) | 2007-03-08 | — | — | US | claimed |
| CN-1701061-A | Novel compounds for inhibiting rotamase enzymes and uses thereof | JERINI AG (DE) | 2005-11-23 | — | — | CN | claimed |
| EP-2100876-A2 | New compounds for the inhibition of rotamases and use thereof | Jerini AG (DE) | 2009-09-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110065760-A1 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES AND USE THEREOF | NR1I3, NR1D1, NR1D2 | GRIK1 21/4885EPHX2 769/4885CHRNA7 416/4885 |
| US-20070054904-A1 | Phenol derivatives and their use as rotamase inhibitors | NR1I3, NR1D1, NR1D2 | GRIK1 54/4885EPHX2 627/4885CHRNA7 700/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.