Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | ITGB2 | P05107 | 6/20 | 0.51 |
| ▸ | ICAM1 | P05362 | 6/20 | 0.51 |
| ▸ | ITGAL | P20701 | 6/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4349270 | 1.00 | ALDH1A1 (0.52) | ALDH1A1TSHRITGB2ICAM1ITGAL | |
| SCHEMBL4348286 | 0.82 | SMN1; SMN2 (0.47) | ALDH1A1KDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL4348279 | 0.82 | SMN1; SMN2 (0.47) | ALDH1A1KDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL4357217 | 0.81 | GSK3B (0.49) | SMN1; SMN2KMT2A | |
| SCHEMBL4357208 | 0.81 | GSK3B (0.49) | SMN1; SMN2KMT2A | |
| SCHEMBL4343023 | 0.77 | GSK3B (0.61) | ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL4343018 | 0.77 | GSK3B (0.61) | ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL7993255 | 0.75 | ALDH1A1 (0.47) | ALDH1A1TSHRKDM4EHSD17B10SMN1; SMN2 | |
| SCHEMBL4351407 | 0.74 | HPGD (0.49) | ALDH1A1KDM4ESMN1; SMN2RAB9ANPC1 | |
| SCHEMBL4351400 | 0.74 | HPGD (0.49) | ALDH1A1KDM4ESMN1; SMN2RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2070928-A1 | 7-azaindol-3-ylacrylamides active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-06-17 | — | — | EP | claimed |
| EP-2070928-A1 | 7-azaindol-3-ylacrylamides active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-06-17 | — | — | EP | disclosed |