Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 7/20 | 0.46 |
| ▸ | DRD3 | P35462 | 6/20 | 0.46 |
| ▸ | HTR1D | P28221 | 2/20 | 0.46 |
| ▸ | HTR1B | P28222 | 2/20 | 0.46 |
| ▸ | CCR2 | P41597 | 4/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4348279 | 1.00 | SMN1; SMN2 (0.47) | SMN1; SMN2DRD2DRD3HTR1DHTR1B | |
| SCHEMBL4357208 | 0.86 | GSK3B (0.49) | SMN1; SMN2DRD2DRD3HTR1DHTR1B | |
| SCHEMBL4357217 | 0.86 | GSK3B (0.49) | SMN1; SMN2DRD2DRD3HTR1DHTR1B | |
| SCHEMBL4343018 | 0.83 | GSK3B (0.61) | SMN1; SMN2KDM4EGSK3BALDH1A1 | |
| SCHEMBL4343023 | 0.83 | GSK3B (0.61) | SMN1; SMN2KDM4EGSK3BALDH1A1 | |
| SCHEMBL4349262 | 0.82 | ALDH1A1 (0.52) | SMN1; SMN2KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL4349270 | 0.82 | ALDH1A1 (0.52) | SMN1; SMN2KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL4343966 | 0.81 | CLK1 (0.51) | DRD2DRD3GSK3B | |
| SCHEMBL4343971 | 0.81 | CLK1 (0.51) | DRD2DRD3GSK3B | |
| SCHEMBL4346646 | 0.79 | GPR88 (0.43) | SMN1; SMN2GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2070928-A1 | 7-azaindol-3-ylacrylamides active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-06-17 | — | — | EP | claimed |
| EP-2070928-A1 | 7-azaindol-3-ylacrylamides active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-06-17 | — | — | EP | disclosed |