Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 3/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CCR2 | P41597 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | HTR1B | P28222 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | WNT1 | P04628 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4357208 | 1.00 | GSK3B (0.49) | GSK3BCYP3A4CYP2C19KMT2APARP1 | |
| SCHEMBL4343023 | 0.91 | GSK3B (0.61) | GSK3BCYP3A4CYP2C19SMN1; SMN2ACHE | |
| SCHEMBL4343018 | 0.91 | GSK3B (0.61) | GSK3BCYP3A4CYP2C19SMN1; SMN2ACHE | |
| SCHEMBL4348286 | 0.86 | SMN1; SMN2 (0.47) | GSK3BSMN1; SMN2CCR2DRD2HTR1D | |
| SCHEMBL4348279 | 0.86 | SMN1; SMN2 (0.47) | GSK3BSMN1; SMN2CCR2DRD2HTR1D | |
| SCHEMBL4349262 | 0.81 | ALDH1A1 (0.52) | KMT2ASMN1; SMN2 | |
| SCHEMBL4349270 | 0.81 | ALDH1A1 (0.52) | KMT2ASMN1; SMN2 | |
| SCHEMBL4355475 | 0.81 | ROCK2 (0.47) | GSK3BKMT2ADYRK1A | |
| SCHEMBL4355471 | 0.81 | ROCK2 (0.47) | GSK3BKMT2ADYRK1A | |
| SCHEMBL4350722 | 0.79 | AURKA (0.46) | GSK3BKMT2AHDAC1HDAC6MTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2070928-A1 | 7-azaindol-3-ylacrylamides active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-06-17 | — | — | EP | claimed |
| EP-2070928-A1 | 7-azaindol-3-ylacrylamides active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-06-17 | — | — | EP | disclosed |