Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | PREP | P48147 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3047400 | 0.88 | ALDH1A1 (0.47) | POLBRXFP1ALDH1A1MAPTHPGD | |
| SCHEMBL3042587 | 0.85 | POLB (0.69) | POLBTSHRALDH1A1MAPTNPSR1 | |
| SCHEMBL3050521 | 0.79 | POLB (0.71) | POLBSIGMAR1ALDH1A1MAPTNPSR1 | |
| SCHEMBL3049283 | 0.77 | POLB (0.65) | POLBSIGMAR1ALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL9540114 | 0.73 | L3MBTL1 (0.61) | POLBTSHRALDH1A1MAPTNPSR1 | |
| SCHEMBL3051897 | 0.71 | POLB (0.73) | POLBTSHRALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL28483843 | 0.71 | ALDH1A1 (0.47) | POLBSIGMAR1ALDH1A1MAPTNPC1 | |
| SCHEMBL30522694 | 0.71 | ALDH1A1 (0.47) | POLBSIGMAR1ALDH1A1MAPTNPC1 | |
| SCHEMBL4340461 | 0.70 | POLB (0.57) | POLBSIGMAR1ALDH1A1NPSR1SMN1; SMN2 | |
| SCHEMBL3045304 | 0.70 | HTR2A (0.45) | POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1434765-B1 | SUBSTITUTED PIPERIDINES WITH SELECTIVE BINDING TO HISTAMINE H3-RECEPTOR | HIGH POINT PHARMACEUTICALS LLC (US) | 2009-12-02 | — | — | EP | claimed |