Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 10/20 | 0.59 |
| ▸ | NPC1 | O15118 | 8/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.59 |
| ▸ | PKM | P14618 | 3/20 | 0.59 |
| ▸ | TP53 | P04637 | 2/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.47 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.47 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4196168 | 0.89 | RAB9A (0.58) | RAB9ANPC1SMN1; SMN2PKMTP53 | |
| SCHEMBL4190145 | 0.85 | KMT2A (0.59) | RAB9ANPC1SMN1; SMN2PKMTP53 | |
| SCHEMBL3585640 | 0.85 | RAB9A (0.81) | RAB9ANPC1SMN1; SMN2PKMTP53 | |
| SCHEMBL774807 | 0.84 | LCK (0.64) | RAB9ANPC1SMN1; SMN2PKMTP53 | |
| SCHEMBL3579989 | 0.84 | SCD (0.64) | RAB9ANPC1SMN1; SMN2PKMTP53 | |
| SCHEMBL3595226 | 0.82 | ALOX5 (0.64) | RAB9ANPC1SMN1; SMN2PKMHTT | |
| SCHEMBL27707040 | 0.82 | NPC1 (0.46) | RAB9ANPC1SMN1; SMN2PKMTP53 | |
| SCHEMBL3581996 | 0.80 | KDM4E (0.67) | RAB9ANPC1SMN1; SMN2PKMALOX15 | |
| SCHEMBL4187299 | 0.79 | NPC1 (0.56) | RAB9ANPC1SMN1; SMN2PKMTP53 | |
| SCHEMBL4194373 | 0.78 | DHODH (0.58) | RAB9ANPC1SMN1; SMN2PKMTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029138-A1 | AMINOTHIAZOLE DERIVATIVES AS HUMAN STEAROYL-COA DESATURASE INHIBITORS | XENON PHARMACEUTICALS INC. (CA) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007130075-A1 | AMINOTHIAZOLE DERIVATIVES AS HUMAN STEAROYL-COA DESATURASE INHIBITORS | XENON PHARMACEUTICALS INC. (CA) | 2007-11-15 | — | — | WO | disclosed |