SCHEMBL4190145

SCHEMBL4190145

Cc1nc(NC(=O)c2ccc(F)cc2Cl)sc1C(=O)O

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.59
RXFP1 Q9HBX9 3/20 0.59
KDM4E B2RXH2 2/20 0.58
RAB9A P51151 6/20 0.55
NPC1 O15118 5/20 0.55
NPSR1 Q6W5P4 2/20 0.55
GLA P06280 1/20 0.55
CTDSP1 Q9GZU7 1/20 0.55
ALDH1A1 P00352 3/20 0.54
MEN1 O00255 2/20 0.54
POLB P06746 1/20 0.54
MAPT P10636 1/20 0.54
HPGD P15428 1/20 0.54
PYGL P06737 1/20 0.52
PKM P14618 2/20 0.51
TP53 P04637 2/20 0.51
ALOX15 P16050 1/20 0.51
HTT P42858 1/20 0.51
SMN1; SMN2 Q16637 1/20 0.51
HSD17B10 Q99714 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4194373 0.88 DHODH (0.58) KMT2ARXFP1KDM4ERAB9ANPC1
SCHEMBL4350870 0.85 RAB9A (0.59) KMT2ARXFP1KDM4ERAB9ANPC1
SCHEMBL3587765 0.84 SCD (0.61) KMT2ARXFP1KDM4ERAB9ANPC1
SCHEMBL28943992 0.82 KMT2A (0.47) KMT2ARXFP1KDM4ERAB9ANPC1
SCHEMBL4196168 0.82 RAB9A (0.58) KMT2ARXFP1KDM4ERAB9ANPC1
SCHEMBL3595226 0.80 ALOX5 (0.64) KMT2ARXFP1KDM4ERAB9ANPC1
SCHEMBL3581996 0.78 KDM4E (0.67) KMT2ARXFP1KDM4ERAB9ANPC1
SCHEMBL3585640 0.78 RAB9A (0.81) KMT2ARXFP1RAB9ANPC1NPSR1
SCHEMBL4187299 0.77 NPC1 (0.56) KMT2ARXFP1KDM4ERAB9ANPC1
SCHEMBL4188640 0.77 NPC1 (0.60) KMT2ARXFP1KDM4ERAB9ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2029138-A1 AMINOTHIAZOLE DERIVATIVES AS HUMAN STEAROYL-COA DESATURASE INHIBITORS XENON PHARMACEUTICALS INC. (CA) 2009-03-04 EP disclosed
WO-2007130075-A1 AMINOTHIAZOLE DERIVATIVES AS HUMAN STEAROYL-COA DESATURASE INHIBITORS XENON PHARMACEUTICALS INC. (CA) 2007-11-15 WO disclosed