Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 4/20 | 0.41 |
| ▸ | CHUK | O15111 | 4/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.37 |
| ▸ | CAMKK2 | Q96RR4 | 4/20 | 0.37 |
| ▸ | INSR | P06213 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4344137 | 0.92 | BRD4 (0.43) | BRD4CHUKMAPK8CAMKK2INSR | |
| SCHEMBL4357005 | 0.91 | BRD4 (0.42) | BRD4CHUKMAPK8CAMKK2INSR | |
| SCHEMBL13685462 | 0.81 | BRD4 (0.47) | BRD4CHUKMAPK8CAMKK2INSR | |
| SCHEMBL2199389 | 0.80 | KDM4E (0.54) | BRD4CHUKMAPK8CAMKK2INSR | |
| SCHEMBL4340973 | 0.80 | BRD4 (0.41) | BRD4CHUKMAPK8CAMKK2INSR | |
| SCHEMBL4344535 | 0.79 | USP2 (0.55) | CHUKMAPK8CAMKK2INSRKDM4E | |
| SCHEMBL4339928 | 0.79 | CCNT1 (0.37) | BRD4KDM4EALDH1A1HPGD | |
| SCHEMBL4350108 | 0.78 | SLC9A1 (0.38) | BRD4ALDH1A1MAPTALOX15SMN1; SMN2 | |
| SCHEMBL2196927 | 0.77 | CDC7 (0.54) | BRD4CHUKMAPK8CAMKK2INSR | |
| SCHEMBL2198565 | 0.75 | BRD4 (0.50) | BRD4CHUKMAPK8CAMKK2INSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2116530-B1 | NOVEL PYRROLE DERIVATIVE HAVING UREIDE GROUP AND AMINOCARBONYL GROUP AS SUBSTITUENTS | SANTEN PHARMACEUTICAL CO LTD (JP) | 2012-11-14 | — | — | EP | disclosed |
| EP-2116530-A1 | NOVEL PYRROLE DERIVATIVE HAVING UREIDE GROUP AND AMINOCARBONYL GROUP AS SUBSTITUENTS | Santen Pharmaceutical Co., Ltd (JP) | 2009-11-11 | — | — | EP | disclosed |