Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.63 |
| ▸ | GSK3B | P49841 | 3/20 | 0.62 |
| ▸ | BACE1 | P56817 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.57 |
| ▸ | PPARG | P37231 | 1/20 | 0.57 |
| ▸ | PPARD | Q03181 | 1/20 | 0.57 |
| ▸ | PPARA | Q07869 | 1/20 | 0.57 |
| ▸ | CA12 | O43570 | 1/20 | 0.56 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.56 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.56 |
| ▸ | CA4 | P22748 | 1/20 | 0.56 |
| ▸ | CA6 | P23280 | 1/20 | 0.56 |
| ▸ | CA5A | P35218 | 1/20 | 0.56 |
| ▸ | CA7 | P43166 | 1/20 | 0.56 |
| ▸ | CA9 | Q16790 | 1/20 | 0.56 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.56 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2239306 | 1.00 | MAOB (0.63) | MAOBGSK3BBACE1MAPTLMNA | |
| SCHEMBL435193 | 1.00 | MAOB (0.63) | MAOBGSK3BBACE1MAPTLMNA | |
| SCHEMBL839208 | 0.87 | LMNA (0.75) | MAOBGSK3BBACE1MAPTLMNA | |
| SCHEMBL16689985 | 0.87 | LMNA (0.75) | MAOBGSK3BBACE1MAPTLMNA | |
| SCHEMBL16689983 | 0.87 | LMNA (0.75) | MAOBGSK3BBACE1MAPTLMNA | |
| SCHEMBL17603656 | 0.87 | LMNA (0.75) | MAOBGSK3BBACE1MAPTLMNA | |
| SCHEMBL15239147 | 0.86 | THRB (0.73) | MAOBGSK3BBACE1FFAR1PPARG | |
| SCHEMBL15239146 | 0.86 | THRB (0.73) | MAOBGSK3BBACE1FFAR1PPARG | |
| SCHEMBL15687587 | 0.86 | LMNA (0.77) | MAOBGSK3BBACE1MAPTLMNA | |
| SCHEMBL15687588 | 0.86 | LMNA (0.77) | MAOBGSK3BBACE1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2595952-B1 | AGONISTS OF GPR40 | CONNEXIOS LIFE SCIENCES PVT LTD (IN) | 2020-11-18 | — | — | EP | disclosed |
| EP-2595952-A1 | AGONISTS OF GPR40 | Connexios Life Sciences Pvt. Ltd. (IN) | 2013-05-29 | — | — | EP | disclosed |
| WO-2012011125-A1 | AGONISTS OF GPR40 | CONNEXIOS LIFE SCIENCES PVT. LTD. (IN) | 2012-01-26 | — | — | WO | disclosed |