Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 8/20 | 0.39 |
| ▸ | THRA | P10827 | 7/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.36 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4351934 | 0.92 | THRA (0.42) | SMN1; SMN2MEN1KMT2ATHRBTHRA | |
| SCHEMBL4932888 | 0.90 | SMN1; SMN2 (0.39) | SMN1; SMN2MEN1KMT2ATHRBTHRA | |
| SCHEMBL4931943 | 0.90 | HPGD (0.39) | SMN1; SMN2MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL4932371 | 0.89 | SMN1; SMN2 (0.39) | SMN1; SMN2MEN1KMT2ATHRBTHRA | |
| SCHEMBL4360612 | 0.87 | THRA (0.51) | SMN1; SMN2MEN1KMT2ATHRBTHRA | |
| SCHEMBL5717937 | 0.87 | THRA (0.44) | MEN1KMT2AMCL1THRBTHRA | |
| SCHEMBL4923977 | 0.87 | SMN1; SMN2 (0.37) | SMN1; SMN2MEN1KMT2ATHRBTHRA | |
| SCHEMBL4931455 | 0.87 | THRA (0.41) | SMN1; SMN2MEN1KMT2ATHRBTHRA | |
| SCHEMBL5718180 | 0.86 | MEN1 (0.36) | SMN1; SMN2MEN1KMT2ATHRBTHRA | |
| SCHEMBL4354094 | 0.85 | THRB (0.50) | SMN1; SMN2MEN1KMT2ATHRBTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009080835-A1 | THYROMIMETRIC COMPOUNDS IN TREATMENT OF DISEASE RELATED TO SONIC HEDGEHOG SIGNALLING | KARO BIO AB (SE) | 2009-07-02 | — | — | WO | claimed |
| US-20080221210-A1 | Thyroid Receptor Agonists | KARO BIO AB (SE) | 2008-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221210-A1 | Thyroid Receptor Agonists | TSHR, TRHR, THRA | SMN1; SMN2 4282/4885MEN1 773/4885KMT2A 1742/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.