Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 18/20 | 0.73 |
| ▸ | THRA | P10827 | 15/20 | 0.73 |
| ▸ | RORC | P51449 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5390894 | 0.89 | THRB (0.75) | THRBTHRARORC | |
| SCHEMBL4566353 | 0.89 | THRB (0.56) | THRBTHRARORC | |
| SCHEMBL5392866 | 0.85 | THRA (1.00) | THRBTHRA | |
| SCHEMBL5396339 | 0.84 | THRB (0.79) | THRBTHRARORC | |
| SCHEMBL5385245 | 0.82 | THRB (0.82) | THRBTHRARORCKDM4E | |
| SCHEMBL5382651 | 0.81 | THRB (0.78) | THRBTHRARORCKDM4E | |
| SCHEMBL4524227 | 0.81 | THRB (0.77) | THRBTHRARORC | |
| SCHEMBL7204449 | 0.80 | THRB (0.75) | THRBTHRARORCKDM4E | |
| SCHEMBL5387224 | 0.80 | THRB (0.81) | THRBTHRARORC | |
| SCHEMBL5388459 | 0.79 | THRB (0.81) | THRBTHRARORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009080835-A1 | THYROMIMETRIC COMPOUNDS IN TREATMENT OF DISEASE RELATED TO SONIC HEDGEHOG SIGNALLING | KARO BIO AB (SE) | 2009-07-02 | — | — | WO | claimed |