Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 16/20 | 0.75 |
| ▸ | THRA | P10827 | 13/20 | 0.75 |
| ▸ | RORC | P51449 | 3/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5385245 | 0.89 | THRB (0.82) | THRBTHRARORCCA12CA1 | |
| SCHEMBL5382651 | 0.86 | THRB (0.78) | THRBTHRARORCKDM4EMEN1 | |
| SCHEMBL5392866 | 0.86 | THRA (1.00) | THRBTHRA | |
| SCHEMBL5396335 | 0.82 | THRB (0.74) | THRBTHRARORCCA12CA1 | |
| SCHEMBL5390894 | 0.81 | THRB (0.75) | THRBTHRARORC | |
| SCHEMBL5387224 | 0.81 | THRB (0.81) | THRBTHRARORC | |
| SCHEMBL5388459 | 0.80 | THRB (0.81) | THRBTHRARORC | |
| SCHEMBL4524227 | 0.80 | THRB (0.77) | THRBTHRARORC | |
| SCHEMBL5387389 | 0.80 | THRA (0.88) | THRBTHRA | |
| SCHEMBL4352291 | 0.80 | THRB (0.73) | THRBTHRARORCKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1296936-A1 | THYROID RECEPTOR LIGANDS, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND THEIR USE IN THE TREATMENT OF DISORDERS INFLUENCED BY THYROID HORMONES | KARO BIO AB (SE) | 2003-04-02 | — | — | EP | disclosed |
| WO-2001098256-A1 | THYROID RECEPTOR LIGANDS, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND THEIR USE IN THE TREATMENT OF DISORDERS INFLUENCED BY THYROID HORMONES | KARO BIO AB (SE) | 2001-12-27 | — | — | WO | disclosed |