Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 17/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.35 |
| ▸ | RBP4 | P02753 | 1/20 | 0.32 |
| ▸ | TTR | P02766 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4352885 | 0.82 | FFAR4 (0.46) | FAAHFFAR4 | |
| SCHEMBL1026507 | 0.81 | KDM4E (0.47) | FAAHRBP4TTR | |
| SCHEMBL13622705 | 0.79 | FFAR4 (0.41) | FAAHFFAR4 | |
| SCHEMBL4357935 | 0.77 | CHRM4 (0.40) | FFAR4 | |
| SCHEMBL1025273 | 0.77 | ITGB3 (0.45) | — | |
| SCHEMBL1024330 | 0.77 | ALDH1A1 (0.52) | — | |
| SCHEMBL1023389 | 0.77 | KDM4E (0.50) | — | |
| SCHEMBL4364569 | 0.76 | LSS (0.43) | FFAR4 | |
| SCHEMBL4365334 | 0.76 | CHRM4 (0.48) | FFAR4RBP4TTR | |
| SCHEMBL4359941 | 0.76 | CHRM4 (0.51) | FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8871753-B2 | Macrocyclic compounds and their use as kinase inhibitors | INCYTE CORPORATION (US) | 2014-10-28 | — | — | US | disclosed |
| US-20090286778-A1 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2009-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286778-A1 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | JAK2, JAK1, ALK | FAAH 2276/4885FFAR4 2075/4885RBP4 4612/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.