Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 18/20 | 0.46 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13622705 | 0.92 | FFAR4 (0.41) | FFAR4FAAHITGB3ITGA2B | |
| SCHEMBL4352889 | 0.82 | FAAH (0.37) | FFAR4FAAH | |
| Trifluoroacetic Acid SCHEMBL1024081 | 0.79 | KDM4E (0.54) | FFAR4 | |
| Trifluoroacetic Acid SCHEMBL1026518 | 0.76 | FFAR4 (0.49) | FFAR4ITGB3ITGA2B | |
| Trifluoroacetic Acid SCHEMBL1025272 | 0.75 | ITGB3 (0.59) | FFAR4ITGB3ITGA2B | |
| Trifluoroacetic Acid SCHEMBL1023388 | 0.75 | DPP4 (0.53) | FFAR4 | |
| Trifluoroacetic Acid SCHEMBL1024329 | 0.75 | ALDH1A1 (0.55) | FFAR4 | |
| Trifluoroacetic Acid SCHEMBL1026170 | 0.75 | FFAR4 (0.59) | FFAR4 | |
| Trifluoroacetic Acid SCHEMBL1026901 | 0.75 | FFAR4 (0.51) | FFAR4 | |
| Trifluoroacetic Acid SCHEMBL1025514 | 0.75 | FFAR4 (0.56) | FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8871753-B2 | Macrocyclic compounds and their use as kinase inhibitors | INCYTE CORPORATION (US) | 2014-10-28 | — | — | US | disclosed |
| US-20090286778-A1 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2009-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286778-A1 | MACROCYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | JAK2, JAK1, ALK | FFAR4 2075/4885FAAH 2276/4885ITGB3 2933/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.