Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | KDM2A | Q9Y2K7 | 4/20 | 0.40 |
| ▸ | KDM3A | Q9Y4C1 | 4/20 | 0.40 |
| ▸ | KDM5C | P41229 | 3/20 | 0.40 |
| ▸ | KDM6B | O15054 | 2/20 | 0.40 |
| ▸ | JMJD6 | Q6NYC1 | 2/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | NQO2 | P16083 | 3/20 | 0.33 |
| ▸ | CCR1 | P32246 | 1/20 | 0.32 |
| ▸ | CCR5 | P51681 | 1/20 | 0.32 |
| ▸ | CCR8 | P51685 | 1/20 | 0.32 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | TOP1 | P11387 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | CASP1 | P29466 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4356178 | 0.80 | NQO2 (0.46) | NQO2ALDH1A1TOP1HPGDCASP1 | |
| SCHEMBL5485823 | 0.78 | APP (0.39) | FAAHNQO2ALDH1A1TOP1HPGD | |
| SCHEMBL5493324 | 0.72 | NQO2 (0.45) | NQO2ALDH1A1TOP1HPGDCASP1 | |
| SCHEMBL3504227 | 0.71 | NQO2 (0.57) | NQO2ALDH1A1TOP1HPGDCASP1 | |
| Pafuramidine SCHEMBL5143735 | 0.71 | NQO2 (0.57) | NQO2ALDH1A1TOP1HPGDCASP1 | |
| SCHEMBL5489885 | 0.67 | PRMT1 (0.59) | NQO2ALDH1A1TOP1HPGDCASP1 | |
| SCHEMBL8296085 | 0.66 | PARP1 (0.48) | HSD17B10 | |
| SCHEMBL8481624 | 0.65 | ALDH1A1 (0.56) | ALDH1A1 | |
| SCHEMBL4952348 | 0.65 | ALDH1A1 (0.44) | KDM4EKDM5CNQO2ALDH1A1TOP1 | |
| Hydrochloric Acid SCHEMBL8485517 | 0.64 | ALDH1A1 (0.54) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7517893-B2 | Bichalcophenes and their prodrugs as antiprotozoal agents | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2009-04-14 | — | — | US | claimed |
| EP-1726589-B1 | 5,5'-bis-(4-amidinophenyl)-2,2'-bifuran derivatives and related compounds as antiprotozoal agent and prodrugs thereof | UNIV NORTH CAROLINA (US) | 2008-10-15 | — | — | EP | claimed |
| US-20060293540-A1 | Novel bichalcophenes and their prodrugs as antiprotozoal agents | TIDWELL RICHARD R | 2006-12-28 | — | — | US | claimed |
| EP-1726589-A2 | 5,5'-bis-(4-amidinophenyl)-2,2'-bifuran derivatives and related compounds as antiprotozoal agent and prodrugs thereof | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2006-11-29 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060293540-A1 | Novel bichalcophenes and their prodrugs as antiprotozoal agents | CASP7, DDT, BAD | KDM4C 1418/4885KDM4E 1472/4885KDM2A 2525/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.