Pafuramidine

Pafuramidine

SCHEMBL5143735

CONC(=N)c1ccc(-c2ccc(-c3ccc(C(=N)NOC)cc3)o2)cc1

nearest known ligand 0.57

Full drug profile on Sugi Atlas →

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ NQO2 P16083 13/20 0.57
▸ PRMT1 Q99873 2/20 0.56
▸ ALDH1A1 P00352 1/20 0.56
▸ TOP1 P11387 1/20 0.56
▸ HPGD P15428 1/20 0.56
▸ CASP1 P29466 1/20 0.56
▸ CASP7 P55210 1/20 0.56
▸ HSD17B10 Q99714 1/20 0.56
▸ TDP1 Q9NUW8 1/20 0.56
▸ TOP2A P11388 3/20 0.55
▸ TOP2B Q02880 3/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3504227 1.00 NQO2 (0.57) NQO2PRMT1ALDH1A1TOP1HPGD
SCHEMBL398449 0.90 NQO2 (0.48) NQO2PRMT1ALDH1A1TOP1HPGD
SCHEMBL3506133 0.89 NQO2 (0.47) NQO2PRMT1ALDH1A1TOP1HPGD
Maleic Acid SCHEMBL3508868 0.88 NQO2 (0.52) NQO2PRMT1ALDH1A1TOP1HPGD
Pafuramidine SCHEMBL29711459 0.88 NQO2 (0.52) NQO2PRMT1ALDH1A1TOP1HPGD
SCHEMBL5489885 0.86 PRMT1 (0.59) NQO2PRMT1ALDH1A1TOP1HPGD
SCHEMBL5493324 0.86 NQO2 (0.45) NQO2PRMT1ALDH1A1TOP1HPGD
SCHEMBL6004202 0.81 NQO2 (0.51) NQO2PRMT1ALDH1A1TOP1HPGD
SCHEMBL4952348 0.80 ALDH1A1 (0.44) NQO2PRMT1ALDH1A1TOP1HPGD
SCHEMBL5485793 0.79 NQO2 (0.53) NQO2PRMT1ALDH1A1TOP1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025133260-A1 INHIBITORS OF PLASMODIA REMODELING ENZYMES UNIVERSITÄT REGENSBURG, IN VERTRETUNG DES FREISTAATES BAYERN (DE) 2025-06-26 — — WO claimed
EP-4574143-A1 INHIBITORS OF PLASMODIA REMODELING ENZYMES Universität Regensburg (DE) 2025-06-25 — — EP claimed
WO-2025111482-A1 COMPLEXING AGENT SALT FORMULATIONS OF PHARMACEUTICAL COMPOUNDS AT LOW STOICHIOMETRIC RATIOS BEXSON BIOMEDICAL, INC. (US) 2025-05-30 — — WO claimed
EP-4525870-A1 METHODS OF TREATING CUSHING'S SYNDROME AND LIVER DISORDERS, AND OF REDUCING LIVER TOXICITY OF OTHER DRUGS ADMINISTERED TO A PATIENT Corcept Therapeutics Incorporated (US) 2025-03-26 — — EP claimed
WO-2024264013-A1 BIOAVAILABILITY ENHANCING IONIC LIQUID FORMULATIONS AND USES THEREOF ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) 2024-12-26 — — WO claimed
US-20240245659-A1 Methods of Treating Cushing's Syndrome and Liver Disorders, and of Reducing Liver Toxicity of Other Drugs Administered to a Patient CORCEPT THERAPEUTICS INCORPORATED (US) 2024-07-25 — — US claimed
WO-2023225282-A1 METHODS OF TREATING CUSHING'S SYNDROME AND LIVER DISORDERS, AND OF REDUCING LIVER TOXICITY OF OTHER DRUGS ADMINISTERED TO A PATIENT CORCEPT THERAPEUTICS INCORPORATED (US) 2023-11-23 — — WO claimed
US-20230372312-A1 Methods of Treating Cushing's syndrome and Liver Disorders, and of Reducing Liver Toxicity of Other Drugs Administered to a Patient CORCEPT THERAPEUTICS INCORPORATED (US) 2023-11-23 — — US claimed
US-20070276020-A1 Dicationic Compounds For Activity Against Trichomonas Vaginalis NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2007-11-29 — — US claimed
WO-2005086754-A2 DICATIONIC COMPOUNDS FOR ACTIVITY AGAINST TRICHOMONAS VAGINALIS GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) 2005-09-22 — — WO claimed
WO-2026090318-A2 ENCAPSULATION COMPOSITIONS AND METHODS FOR ENCAPSULATING ACTIVE AGENTS DEFY-Tech Labs, Inc. (US) 2026-04-30 — — WO disclosed
US-20260108444-A1 ENCAPSULATION COMPOSITIONS AND METHODS FOR ENCAPSULATING ACTIVE AGENTS DEFY TECH LABS INC (US) 2026-04-23 — — US disclosed
US-20250368679-A1 FORMATION OF AMIDINES VANVELLER BRETT (US) 2025-12-04 — — US disclosed
US-20250312349-A1 COMPOSITION AND METHODS OF TREATING INTRACELLULAR PATHOGEN INFECTION UNIV HOSPITALS CLEVELAND MEDICAL CENTER (US) 2025-10-09 — — US disclosed
WO-2025133260-A1 INHIBITORS OF PLASMODIA REMODELING ENZYMES UNIVERSITÄT REGENSBURG, IN VERTRETUNG DES FREISTAATES BAYERN (DE) 2025-06-26 — — WO disclosed
WO-2005086754-A2 DICATIONIC COMPOUNDS FOR ACTIVITY AGAINST TRICHOMONAS VAGINALIS GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) 2005-09-22 — — WO disclosed
WO-2005086808-A2 NOVEL DICATIONIC IMIDAZO[1,2-a]PYRIDINES AND 5,6,7,8-TETRAHYDRO-IMIDAZO[1,2a]PYRIDINES AS ANTIPROTOZOAL AGENTS THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 2005-09-22 — — WO disclosed
EP-1565457-A2 PROCESS FOR SYNTHESIS BIS-ARYL DIAMIDOXIME COMPOUNDS UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 2005-08-24 — — EP disclosed
US-20040127721-A1 Process for the synthesis of bis-aryl diamidoxime compounds UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL 2004-07-01 — — US disclosed
WO-2004051217-A2 PROCESS FOR SYNTHESIS BIS-ARYL DIAMIDOXIME COMPOUNDS UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 2004-06-17 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260108444-A1 ENCAPSULATION COMPOSITIONS AND METHODS FOR ENCAPSULATING ACTIVE AGENTS LIPA, LIPC, ACACA NQO2 3127/4885PRMT1 4613/4885ALDH1A1 1598/4885
US-20250368679-A1 FORMATION OF AMIDINES H1-4, H1-2, H1-3 NQO2 640/4885PRMT1 50/4885ALDH1A1 3396/4885
US-20240245659-A1 Methods of Treating Cushing's Syndrome and Liver Disorders, and of Reducing Liver Toxicity of Other Drugs Administered to a Patient CYP3A43, NR3C2, CYP3A5 NQO2 1536/4885PRMT1 1379/4885ALDH1A1 463/4885
US-20040127721-A1 Process for the synthesis of bis-aryl diamidoxime compounds DDT, DAO, DDO NQO2 339/4885PRMT1 3200/4885ALDH1A1 586/4885
US-20230372312-A1 Methods of Treating Cushing's syndrome and Liver Disorders, and of Reducing Liver Toxicity of Other Drugs Administered to a Patient CYP3A43, NR3C2, CYP3A5 NQO2 1536/4885PRMT1 1379/4885ALDH1A1 463/4885
US-20070276020-A1 Dicationic Compounds For Activity Against Trichomonas Vaginalis CASP12, DLD, HDAC5 NQO2 1046/4885PRMT1 1577/4885ALDH1A1 3778/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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