Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3327273 | 0.92 | KMT2A (0.72) | PKMALDH1A1MAPK1KMT2APOLB | |
| SCHEMBL6291993 | 0.87 | SIGMAR1 (0.68) | PKMMAPK1KMT2ASIGMAR1NEK1 | |
| SCHEMBL6291901 | 0.85 | SIGMAR1 (0.69) | PKMMAPK1KMT2ASIGMAR1NEK1 | |
| SCHEMBL3719058 | 0.85 | PKM (0.69) | PKMALDH1A1MAPK1KMT2AEPHX2 | |
| SCHEMBL6291984 | 0.83 | SIGMAR1 (0.52) | PKMALDH1A1MAPK1SIGMAR1 | |
| SCHEMBL19563407 | 0.83 | SIGMAR1 (0.76) | PKMALDH1A1MAPK1KMT2AEPHX2 | |
| SCHEMBL31356929 | 0.83 | ALDH1A1 (0.74) | PKMALDH1A1MAPK1KMT2AEPHX2 | |
| SCHEMBL78149 | 0.83 | PKM (0.70) | PKMALDH1A1MAPK1KMT2AEPHX2 | |
| SCHEMBL12302133 | 0.83 | ALDH1A1 (0.74) | PKMALDH1A1MAPK1KMT2AEPHX2 | |
| SCHEMBL3331192 | 0.83 | PKM (0.70) | PKMALDH1A1MAPK1KMT2AEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2885304-B1 | PYRROLOPYRAZOLES AS N-TYPE CALCIUM CHANNEL BLOCKERS | JANSSEN PHARMACEUTICA NV (BE) | 2016-09-21 | — | — | EP | disclosed |
| WO-2009150144-A1 | NEW GPR119MODULATORS | INOVACIA AB (SE) | 2009-12-17 | — | — | WO | disclosed |
| US-6855719-B1 | Imidazo[1,2-A]pyridine and pyrazolo[2,3-A]pyridine derivatives | ASTRAZENECA AB (SE) | 2005-02-15 | — | — | US | disclosed |
| CN-1174981-C | Imidazo [1, 2-A ] pyridine and pyrazolo [2, 3-A ] pyridine derivatives | — | 2004-11-10 | — | — | CN | disclosed |
| EP-1214318-B1 | IMIDAZO[1,2-A]PYRIDINE AND PYRAZOLO[2,3-A]PYRIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2003-10-08 | — | — | EP | disclosed |
| CN-1370163-A | Imidazo [1,2-A] pyridine and pyrazolo [2,3-a] pyridine derivatives | ASTRAZENECA AB (SE) | 2002-09-18 | — | — | CN | disclosed |
| EP-1214318-A1 | IMIDAZO[1,2-A]PYRIDINE AND PYRAZOLO[2,3-A]PYRIDINE DERIVATIVES | AstraZeneca AB (SE) | 2002-06-19 | — | — | EP | disclosed |
| WO-2001014375-A1 | IMIDAZO[1,2-A]PYRIDINE AND PYRAZOLO[2,3-A]PYRIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-03-01 | — | — | WO | disclosed |