Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMPRSS4 | Q9NRS4 | 9/20 | 0.60 |
| ▸ | P2RX1 | P51575 | 6/20 | 0.60 |
| ▸ | P2RX4 | Q99571 | 4/20 | 0.60 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.60 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | IKBKB | O14920 | 1/20 | 0.47 |
| ▸ | CHUK | O15111 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | MYLK | Q15746 | 1/20 | 0.47 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.47 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.45 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | RHOC | P08134 | 1/20 | 0.44 |
| ▸ | RHOA | P61586 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4351946 | 0.88 | P2RX1 (0.53) | TMPRSS4P2RX1P2RX4P2RX7MEN1 | |
| SCHEMBL2838246 | 0.84 | CHRNA7 (0.63) | TMPRSS4P2RX1P2RX4P2RX7MEN1 | |
| SCHEMBL4354221 | 0.84 | P2RX1 (0.46) | TMPRSS4P2RX1P2RX4P2RX7GRIK1 | |
| SCHEMBL4342062 | 0.83 | TMPRSS4 (0.55) | TMPRSS4P2RX1P2RX4P2RX7GRIK1 | |
| SCHEMBL4359745 | 0.82 | TMPRSS4 (0.50) | TMPRSS4P2RX1P2RX4P2RX7CHRNA7 | |
| SCHEMBL4341696 | 0.81 | P2RX1 (0.54) | TMPRSS4P2RX1P2RX4P2RX7MEN1 | |
| SCHEMBL4341321 | 0.80 | P2RX1 (0.50) | TMPRSS4P2RX1P2RX4P2RX7GRIK1 | |
| SCHEMBL4350779 | 0.80 | BAZ1A (0.49) | TMPRSS4P2RX1P2RX4P2RX7MEN1 | |
| SCHEMBL4341759 | 0.78 | P2RX1 (0.41) | TMPRSS4P2RX1P2RX4P2RX7GRIK1 | |
| SCHEMBL4345871 | 0.78 | GRIK1 (0.51) | TMPRSS4GRIK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110065760-A1 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES AND USE THEREOF | JERINI AG (DE) | 2011-03-17 | — | — | US | claimed |
| EP-2100876-A2 | New compounds for the inhibition of rotamases and use thereof | Jerini AG (DE) | 2009-09-16 | — | — | EP | claimed |
| US-20070054904-A1 | Phenol derivatives and their use as rotamase inhibitors | JERINI AG (DE) | 2007-03-08 | — | — | US | claimed |
| EP-2100876-A2 | New compounds for the inhibition of rotamases and use thereof | Jerini AG (DE) | 2009-09-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110065760-A1 | COMPOUNDS FOR THE INHIBITION OF ROTAMASES AND USE THEREOF | NR1I3, NR1D1, NR1D2 | TMPRSS4 630/4885P2RX1 2577/4885P2RX4 2254/4885 |
| US-20070054904-A1 | Phenol derivatives and their use as rotamase inhibitors | NR1I3, NR1D1, NR1D2 | TMPRSS4 379/4885P2RX1 2600/4885P2RX4 2271/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.