Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 4/20 | 0.56 |
| ▸ | DHFR | P00374 | 4/20 | 0.47 |
| ▸ | SRC | P12931 | 2/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.41 |
| ▸ | PRKDC | P78527 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4464780 | 0.86 | FGFR1 (0.55) | FGFR1DHFRSRCPDGFRBPDGFRA | |
| SCHEMBL8122597 | 0.85 | FGFR1 (0.76) | FGFR1DHFRSRCPDGFRBPDGFRA | |
| SCHEMBL4200127 | 0.84 | FGFR1 (0.71) | FGFR1DHFRSRCPDGFRBPDGFRA | |
| SCHEMBL4475729 | 0.83 | FGFR1 (0.47) | FGFR1DHFRSRCADORA1 | |
| SCHEMBL4484811 | 0.81 | DHFR (0.56) | FGFR1DHFRADORA1 | |
| SCHEMBL3959532 | 0.74 | DHFR (0.54) | FGFR1DHFRSRC | |
| SCHEMBL4188897 | 0.72 | DHFR (0.54) | FGFR1DHFRLCKKDRJAK3 | |
| SCHEMBL4357670 | 0.72 | DHFR (0.50) | FGFR1DHFRLCKKDRJAK3 | |
| SCHEMBL975784 | 0.72 | CYP2D6 (0.57) | FGFR1DHFRSRCPDGFRBPDGFRA | |
| SCHEMBL31155969 | 0.72 | NUDT1 (0.48) | FGFR1SRCPDGFRBPDGFRANUDT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2032543-A1 | 2-ANILINO-4-AMINOALKYLENEAMINOPYRIMIDINES | Boehringer Ingelheim International GmbH (DE) | 2009-03-11 | — | — | EP | disclosed |
| WO-2007146977-A1 | 2-ANILINO-4-AMINOALKYLENEAMINOPYRIMIDINES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-12-21 | — | — | WO | disclosed |