SCHEMBL4354384

SCHEMBL4354384

C#Cc1cc(F)ccc1C(=O)c1ccc(-c2ccccc2)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDC25B P30305 2/20 0.51
ATM Q13315 1/20 0.51
CHRNA7 P36544 3/20 0.43
BCL2L1 Q07817 2/20 0.41
BAD Q92934 2/20 0.41
CDC25A P30304 1/20 0.41
HSD17B10 Q99714 1/20 0.41
POLB P06746 2/20 0.40
MEN1 O00255 2/20 0.40
KMT2A Q03164 2/20 0.40
ITGB1 P05556 1/20 0.40
ITGA2 P17301 1/20 0.40
ALDH1A1 P00352 1/20 0.40
DHODH Q02127 1/20 0.40
CA1 P00915 1/20 0.40
CA2 P00918 1/20 0.40
CA9 Q16790 1/20 0.40
KDM4E B2RXH2 1/20 0.40
LMNA P02545 1/20 0.39
MAPT P10636 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4358127 0.84 CDC25B (0.53) CDC25BATMBCL2L1CDC25AHSD17B10
SCHEMBL1746496 0.84 CDC25B (0.47) CDC25BATMCHRNA7BCL2L1BAD
SCHEMBL4354387 0.84 CDC25B (0.47) CDC25BATMCHRNA7BCL2L1BAD
SCHEMBL3611155 0.79 SMN1; SMN2 (0.45) CDC25BATMMEN1KMT2AALDH1A1
SCHEMBL4305925 0.77 ATM (0.53) CDC25BATMMEN1KMT2AALDH1A1
SCHEMBL1773507 0.75 CDC25B (0.51) CDC25BATMCHRNA7BCL2L1BAD
SCHEMBL3296771 0.74 BCL2L1 (0.65) CDC25BATMBCL2L1BADPOLB
SCHEMBL4308501 0.74 NPC1 (0.44) ATMMEN1KMT2AALDH1A1CA2
SCHEMBL1095325 0.73 ACMSD (0.58) CDC25BATM
SCHEMBL14431511 0.73 CES2 (0.59) CDC25BATMCHRNA7BCL2L1BAD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8952200-B2 Liquid crystal oligomer, synthesis composition, preparation method thereof, and liquid crystal material BOE TECHNOLOGY GROUP CO., LTD. (CN) 2015-02-10 US disclosed
US-20120264980-A1 LIQUID CRYSTAL OLIGOMER, SYNTHESIS COMPOSITION, PREPARATION METHOD THEREOF, AND LIQUID CRYSTAL MATERIAL BEIJING BOE DISPLAY TECHNOLOGY CO., LTD (CN) 2012-10-18 US disclosed
EP-1457511-B1 CROSSLINKABLE AROMATIC RESINS HAVING PROTONIC ACID GROUPS AND ION CONDUCTIVE POLYMER MEMBRANES BINDERS AND FUEL CELLS MADE BY USING THE SAME MITSUI CHEMICALS INC (JP) 2009-07-15 EP disclosed
US-20040191602-A1 Crosslinkable aromatic resin having protonic acid group, and ion conductive polymer membrane, binder and fuel cell using the resin MITSUI CHEMICALS, INC. (JP) 2004-09-30 US disclosed
EP-1457511-A1 CROSSLINKABLE AROMATIC RESINS HAVING PROTONIC ACID GROUPS AND ION CONDUCTIVE POLYMER MEMBRANES BINDERS AND FUEL CELLS MADE BY USING THE SAME Mitsui Chemicals, Inc. (JP) 2004-09-15 EP disclosed
US-6191252-B1 BY USING A TRIFUNCTIONAL AMINE OR ANHYDRIDE IN THE POLYMERIZATION PROCEDURE TO FORM BRANCHED OR STAR-SHAPED POLYIMIDES; MOLDINGS, COATINGS, PREPREGS NATIONAL AERONAUTICS AND SPACE ADMINISTRATION (NASA), THE 2001-02-20 US disclosed
US-5965687-A USING A TRIFUNCTIONAL PHENOL IN THE POLYMERIZATION OF POLYETHER MONOMERS TO FORM BRANCHED OR STAR POLYMERS; LOW MELTING POINTS; IMPROVED CHEMICAL RESISTANCE AND MECHANICAL PROPERTIES; RESIN TRANSFER MOLDING AND RESIN FILM INFUSION THE UNITED STATES OF AMERICA REPRESENTED BY THE ADMINSTRATOR OF THE NATIONAL AERONAUTICS AND SPACE ADMINISTRATION (US) 1999-10-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120264980-A1 LIQUID CRYSTAL OLIGOMER, SYNTHESIS COMPOSITION, PREPARATION METHOD THEREOF, AND LIQUID CRYSTAL MATERIAL RNMT, DNMT3A, DNMT1 CDC25B 1975/4885ATM 1208/4885CHRNA7 2458/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.