Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.66 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | NAMPT | P43490 | 2/20 | 0.61 |
| ▸ | HPGD | P15428 | 4/20 | 0.58 |
| ▸ | NPC1 | O15118 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12445445 | 0.90 | SMN1; SMN2 (0.81) | NAAASMN1; SMN2GAAMAPTNAMPT | |
| SCHEMBL25863565 | 0.90 | SMN1; SMN2 (0.74) | NAAASMN1; SMN2GAAMAPTHPGD | |
| SCHEMBL26646791 | 0.89 | HPGD (0.73) | NAAASMN1; SMN2NAMPTHPGDNPC1 | |
| SCHEMBL16361209 | 0.89 | SMN1; SMN2 (0.84) | NAAASMN1; SMN2GAAMAPTNAMPT | |
| SCHEMBL9348556 | 0.88 | SMN1; SMN2 (0.76) | NAAASMN1; SMN2GAAMAPTNAMPT | |
| SCHEMBL1959872 | 0.86 | SMN1; SMN2 (0.73) | NAAASMN1; SMN2GAAMAPTNAMPT | |
| SCHEMBL4039186 | 0.83 | ALDH1A1 (0.83) | NAAASMN1; SMN2GAAHPGDNPC1 | |
| SCHEMBL1002854 | 0.83 | NAAA (0.86) | NAAASMN1; SMN2GAAHPGDNPC1 | |
| SCHEMBL16449001 | 0.82 | SMN1; SMN2 (0.67) | NAAASMN1; SMN2MAPTNAMPTHPGD | |
| Hydrochloric Acid SCHEMBL15954598 | 0.82 | NAAA (0.83) | NAAASMN1; SMN2GAAHPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2056829-A2 | USING PI3K AND MEK MODULATORS IN TREATMENTS OF CANCER | Exelixis, Inc. (US) | 2009-05-13 | — | — | EP | claimed |
| WO-2008021389-A2 | USING PI3K AND MEK MODULATORS IN TREATMENTS OF CANCER | EXELIXIS, INC. (US) | 2008-02-21 | — | — | WO | claimed |