Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | FNTA | P49354 | 1/20 | 0.34 |
| ▸ | FNTB | P49356 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | XDH | P47989 | 1/20 | 0.30 |
| ▸ | ABL1 | P00519 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2076292 | 0.86 | PKM (0.51) | PKMFNTAFNTBTP53KMT2A | |
| SCHEMBL2076352 | 0.86 | TP53 (0.38) | TP53KMT2AKDM4EMEN1ALOX15 | |
| SCHEMBL4190412 | 0.74 | PKM (0.41) | PKMFNTAFNTBKMT2AKDM4E | |
| SCHEMBL4338327 | 0.72 | KDR (0.40) | PKMFNTAFNTBKMT2AKDM4E | |
| SCHEMBL4354692 | 0.68 | TSHR (0.43) | — | |
| SCHEMBL174800 | 0.67 | PKM (0.53) | PKMFNTAFNTBKMT2AKDM4E | |
| SCHEMBL2193196 | 0.66 | PKM (0.55) | PKMFNTAFNTBKMT2AKDM4E | |
| SCHEMBL8234335 | 0.66 | PKM (0.55) | PKMFNTAFNTBKMT2AKDM4E | |
| SCHEMBL8241443 | 0.66 | RECQL (0.35) | KMT2AKDM4EMEN1HSD17B10 | |
| SCHEMBL12427514 | 0.65 | ALDH1A1 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2024360-A2 | SUBSTITUTED PYRAZOLOPYRIMIDINES | Cephalon, Inc. (US) | 2009-02-18 | — | — | EP | disclosed |
| WO-2008063232-A2 | SUBSTITUTED PYRAZOLOPYRIMIDINES | CEPHALON, INC. (US) | 2008-05-29 | — | — | WO | disclosed |