Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 5/20 | 0.43 |
| ▸ | LOXL2 | Q9Y4K0 | 3/20 | 0.42 |
| ▸ | LOX | P28300 | 2/20 | 0.42 |
| ▸ | ACVR2A | P27037 | 1/20 | 0.33 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.33 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | GABRP | O00591 | 1/20 | 0.33 |
| ▸ | GABRD | O14764 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1416713 | 0.81 | ACACB (0.44) | ACACBLOXL2LOXMAPK13MAPK12 | |
| SCHEMBL16453525 | 0.78 | NOS3 (0.48) | ACACBLOXL2LOXMAPK13MAPK12 | |
| SCHEMBL25300735 | 0.77 | LOXL2 (0.66) | ACACBLOXL2LOX | |
| SCHEMBL4018741 | 0.77 | RECQL (0.47) | ACACBLOXL2LOXMAPK13MAPK12 | |
| SCHEMBL2891302 | 0.74 | ACACB (0.41) | ACACBLOXL2LOXMAPK13MAPK12 | |
| SCHEMBL4019820 | 0.74 | LOXL2 (0.41) | ACACBLOXL2LOXACVR2ATGFBR2 | |
| SCHEMBL12093674 | 0.71 | LOXL2 (0.62) | ACACBLOXL2LOXGABRA1GABRB2 | |
| SCHEMBL17000198 | 0.71 | LOXL2 (0.41) | ACACBLOXL2LOXHCRTR1HCRTR2 | |
| SCHEMBL21214848 | 0.70 | GABRA1 (0.42) | ACACBLOXL2LOXGABRPGABRD | |
| SCHEMBL13791786 | 0.69 | CCR1 (0.53) | ACACBLOXL2LOXACVR2ATGFBR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8207194-B2 | Compounds having a 4-pyridylalkylthio group as a substituent | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2012-06-26 | — | — | US | disclosed |
| US-20090286786-A1 | Compounds having a 4-pyridylalkylthio group as a substituent | SANTEN PHARMACEUTICAL CO., LTD. (JP) | 2009-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286786-A1 | Compounds having a 4-pyridylalkylthio group as a substituent | FLT1, FLT4, PYM1 | ACACB 2238/4885LOXL2 1551/4885LOX 985/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.