Paramethasone

Paramethasone

SCHEMBL4355

C[C@@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PGR P06401 7/20 1.00
AR P10275 5/20 1.00
ABCB11 O95342 4/20 0.79
NR3C1 P04150 7/20 0.70
CYP3A4 P08684 9/20 0.66
HSD17B10 Q99714 4/20 0.66
ADRA1A P35348 2/20 0.66
KDM4E B2RXH2 1/20 0.66
LMNA P02545 1/20 0.66
CYP2C19 P33261 1/20 0.66
HTR1A P08908 1/20 0.66
ADRA2A P08913 1/20 0.66
HIF1A Q16665 6/20 0.61
ALDH1A1 P00352 2/20 0.61
MAPT P10636 1/20 0.61
RAB9A P51151 1/20 0.61
SMN1; SMN2 Q16637 1/20 0.61
ABCC4 O15439 1/20 0.60
NR1I2 O75469 1/20 0.60
PDE4D Q08499 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Paramethasone SCHEMBL5188901 1.00 PGR (1.00) PGRARABCB11NR3C1CYP3A4
Paramethasone SCHEMBL11854095 1.00 PGR (1.00) PGRARABCB11NR3C1CYP3A4
Paramethasone SCHEMBL11856144 1.00 PGR (1.00) PGRARABCB11NR3C1CYP3A4
Paramethasone SCHEMBL11862589 1.00 PGR (1.00) PGRARABCB11NR3C1CYP3A4
Paramethasone SCHEMBL11276553 1.00 PGR (1.00) PGRARABCB11NR3C1CYP3A4
Paramethasone SCHEMBL6850206 1.00 PGR (1.00) PGRARABCB11NR3C1CYP3A4
Paramethasone SCHEMBL11126091 1.00 PGR (1.00) PGRARABCB11NR3C1CYP3A4
Paramethasone SCHEMBL11127301 1.00 PGR (1.00) PGRARABCB11NR3C1CYP3A4
Paramethasone SCHEMBL19327163 1.00 PGR (1.00) PGRARABCB11NR3C1CYP3A4
Paramethasone SCHEMBL11421133 1.00 PGR (1.00) PGRARABCB11NR3C1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 14693 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260139030-A1 CHIMERIC PROTEINS FOR TREATING CUTANEOUS INFLAMMATION SHATTUCK LABS INC (US) 2026-05-21 US claimed
WO-2026106917-A1 EDIBLE TRANSMUCOSAL DRUG DELIVERY METHOD USING AN INTERMEDIATE CAPSULE AS A TEMPORARY VESSEL BioPhysics Pharma, Inc. (US) 2026-05-21 WO claimed
WO-2026100654-A1 NUCLEIC ACID INTRODUCTION AID, NUCLEIC ACID INTRODUCTION AGENT, AND NUCLEIC ACID INTRODUCTION METHOD 株式会社インファーマシア 2026-05-15 WO claimed
US-20260125650-A1 METHODS AND COMPOSITIONS FOR GENERATING HEPATOCYTES TRAILHEAD BIOSYSTEMS INC (US) 2026-05-07 US claimed
US-12605345-B2 Transdermal drug delivery system BioPhysics Pharma, Inc. (US) 2026-04-21 US claimed
US-20260103492-A1 CYCLOSPORINE COMPOSITIONS AND METHODS OF USE BACAINN BIOTHERAPEUTICS, LTD. (KY) 2026-04-16 US claimed
EP-4301343-B1 PHARMACEUTICAL COMPOSITIONS WITH REDUCED SIDE EFFECT AND METHODS OF USING THE SAME TLC BIOPHARMACEUTICALS INC (US) 2025-11-19 EP claimed
US-12421281-B2 Cyclosporine compositions and methods of use BACAINN BIOTHERAPEUTICS, LTD. (KY) 2025-09-23 US claimed
US-20250268841-A1 Trans-Epithelial Membrane Drug Delivery System Masiz, John J. (US) 2025-08-28 US claimed
US-20250255781-A1 PROCESSES FOR PREPARATION OF 3-D PRINTED PHARMACEUTICAL PRODUCTS BRISTOL-MYERS SQUIBB COMPANY (US) 2025-08-14 US claimed
US-4317816-A TREATMENT WITH GLUCOCORTICOID AND SAPOININ OF GINSENG OSAKA CHEMICAL LABORATORY CO., LTD. (JP) 1982-03-02 US claimed
US-4312865-A Medication having penetration through cutaneous surfaces into articular and muscular areas SZUCS MURRILL M 1982-01-26 US claimed
EP-0033341-A1 CYTOTOXIC NUCLEOSIDE-CORTICOSTEROID PHOSPHODIESTERS Research Corporation (US) 1981-08-12 EP claimed
US-4283394-A ANTICARCINOGENIC AGENTS RESEARCH CORPORATION (US) 1981-08-11 US claimed
US-4279900-A ANTIINFLAMMATORY INTREX RESEARCH CORPORATION (US) 1981-07-21 US claimed
WO-1981000410-A1 CYTOTOXIC NUCLEOSIDE-CORTICOSTEROID PHOSPHODIESTERS RESEARCH CORP (US) 1981-02-19 WO claimed
US-4221787-A Esteramide prodrugs of anti-inflammatory corticosteroids INTERX RESEARCH CORPORATION (US) 1980-09-09 US claimed
US-4113680-A Method for preparing 17 α-ester-21-halo pregnanes TAISHO PHARMACEUTICAL CO., LTD. (JP) 1978-09-12 US claimed
US-4112073-A Medicinal composition comprising adrenal cortical hormone and thyroid stimulating hormone releasing hormone TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1978-09-05 US claimed
US-4041055-A SULFENYLATION, MICHAEL ADDITION, REACTION WITH THIOPHILE, HYDROLYSIS THE UPJOHN COMPANY (US) 1977-08-09 US claimed