Sugi Predict

Sugi Predict / Compounds / Paramethasone

Paramethasone

Paramethasone

SCHEMBL6850206

CC1C[C@H]2[C@@H]3CC(F)C4=CC(=O)C=C[C@]4(C)[C@H]3[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PGR P06401 7/20 1.00
▸ AR P10275 5/20 1.00
▸ ABCB11 O95342 4/20 0.79
▸ NR3C1 P04150 7/20 0.70
▸ CYP3A4 P08684 9/20 0.66
▸ HSD17B10 Q99714 4/20 0.66
▸ ADRA1A P35348 2/20 0.66
▸ KDM4E B2RXH2 1/20 0.66
▸ LMNA P02545 1/20 0.66
▸ CYP2C19 P33261 1/20 0.66
▸ HTR1A P08908 1/20 0.66
▸ ADRA2A P08913 1/20 0.66
▸ HIF1A Q16665 6/20 0.61
▸ ALDH1A1 P00352 2/20 0.61
▸ MAPT P10636 1/20 0.61
▸ RAB9A P51151 1/20 0.61
▸ SMN1; SMN2 Q16637 1/20 0.61
▸ ABCC4 O15439 1/20 0.60
▸ NR1I2 O75469 1/20 0.60
▸ PDE4D Q08499 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Paramethasone SCHEMBL5188901 1.00 PGR (1.00) PGRARABCB11NR3C1CYP3A4
Paramethasone SCHEMBL11854095 1.00 PGR (1.00) PGRARABCB11NR3C1CYP3A4
Paramethasone SCHEMBL11856144 1.00 PGR (1.00) PGRARABCB11NR3C1CYP3A4
Paramethasone SCHEMBL11862589 1.00 PGR (1.00) PGRARABCB11NR3C1CYP3A4
Paramethasone SCHEMBL11276553 1.00 PGR (1.00) PGRARABCB11NR3C1CYP3A4
Paramethasone SCHEMBL11126091 1.00 PGR (1.00) PGRARABCB11NR3C1CYP3A4
Paramethasone SCHEMBL11127301 1.00 PGR (1.00) PGRARABCB11NR3C1CYP3A4
Paramethasone SCHEMBL19327163 1.00 PGR (1.00) PGRARABCB11NR3C1CYP3A4
Paramethasone SCHEMBL11421133 1.00 PGR (1.00) PGRARABCB11NR3C1CYP3A4
Paramethasone SCHEMBL6850202 1.00 PGR (1.00) PGRARABCB11NR3C1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6830758-B2 Patch containing drug; flexible backing; pressure sensitive adhesive LECTEC CORPORATION 2004-12-14 — — US claimed
US-20030077316-A1 Psoriasis patch AXOGEN CORPORATION 2003-04-24 — — US claimed
US-20020192273-A1 Therapeutic patch useful for the treatment of hemorrhoids LEC TEC CORPORATION 2002-12-19 — — US claimed
EP-0231070-B1 Fluorocarbon blood substitutes ALLIANCE PHARMA (US) 1998-06-10 — — EP claimed
US-5080885-A Brominated perfluorocarbon emulsions for internal animal use for contrast enhancement and oxygen transport ALLIANCE PHARMACEUTICAL CORP. (US) 1992-01-14 — — US claimed
EP-0231070-A2 Fluorocarbon blood substitutes ALLIANCE PHARMACEUTICAL CORP. (US) 1987-08-05 — — EP claimed
US-20230128252-A1 PHARMACEUTICAL COMPOSITIONS Shenzhen Pharmacin Co., Ltd. (CN) 2023-04-27 — — US disclosed
EP-4135699-A1 PHARMACEUTICAL COMPOSITIONS Shenzhen Pharmacin Co., Ltd. (CN) 2023-02-22 — — EP disclosed
EP-3692981-B1 TOPICAL COMPOSITION FOR USE IN THE TREATMENT OF PSORIASIS CHEM CURE ASS LLC (US) 2022-05-04 — — EP disclosed
US-11260063-B2 Method and compositions for treating psoriasis CHEM-CURE ASSOCIATES LLC (US) 2022-03-01 — — US disclosed
WO-2021209025-A1 PHARMACEUTICAL COMPOSITIONS SHENZHEN PHARMACIN CO., LTD (CN) 2021-10-21 — — WO disclosed
US-20210244638-A1 INHIBITORS OF GLYCOSPHINGOLIPID SYNTHESIS AND METHODS OF USE SUBROTO B CHATTERJEE (US) 2021-08-12 — — US disclosed
EP-3692981-A1 TOPICAL COMPOSITION FOR USE IN THE TREATMENT OF PSORIASIS Anaplasi Pharmaceuticals LLC (US) 2020-08-12 — — EP disclosed
EP-0004773-B1 17-BETA-THIOCARBOXYLIC ACID ESTERS OF 4-HALO-3-OXOANDROST-4-ENES, THEIR PHARMACEUTICAL USE AND PROCESSES FOR THEIR PREPARATION SYNTEX (U.S.A.) INC. (US) 1981-04-29 — — EP disclosed
US-4263289-A ANTIINFLAMMATORY STEROIDS SYNTEX (U.S.A.) INC. (US) 1981-04-21 — — US disclosed
US-4246346-A ACTIVATING THE IMMOBILIZED MICROORGANISMS BY ADDING PEPTONE OR GLUCOSE TO THE REACTION MIXTURE AKTIEBOLAGET FERMENTA (SE) 1981-01-20 — — US disclosed
US-4242334-A ANTIINFLAMMATORY AGENTS; SKIN DISORDERS HOECHST AKTIENGESELLSCHAFT (DE) 1980-12-30 — — US disclosed
EP-0004975-A2 17-Alkylcarbonates of corticoids, process for their preparation and their use as medicines against dermatoses HOECHST AKTIENGESELLSCHAFT (DE) 1979-10-31 — — EP disclosed
US-4150120-A Ophthalmic TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1979-04-17 — — US disclosed
US-4112073-A Medicinal composition comprising adrenal cortical hormone and thyroid stimulating hormone releasing hormone TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1978-09-05 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020192273-A1 Therapeutic patch useful for the treatment of hemorrhoids PTGIR, PLOD3, PTGIS PGR 4249/4885AR 2031/4885ABCB11 686/4885
US-20230128252-A1 PHARMACEUTICAL COMPOSITIONS SLCO4C1, SLCO1B1, SLCO1A2 PGR 921/4885AR 2602/4885ABCB11 166/4885
US-20030077316-A1 Psoriasis patch PEF1, ITCH, DSG1 PGR 2861/4885AR 3981/4885ABCB11 913/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.