Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 13/20 | 0.42 |
| ▸ | LPAR5 | Q9H1C0 | 13/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MITF | O75030 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.31 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | F10 | P00742 | 1/20 | 0.31 |
| ▸ | F7 | P08709 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4366116 | 0.90 | LPAR1 (0.36) | LPAR1LPAR5 | |
| SCHEMBL4015362 | 0.88 | LPAR1 (0.43) | LPAR1LPAR5 | |
| SCHEMBL14252000 | 0.88 | LPAR1 (0.41) | LPAR1LPAR5ALDH1A1MAPTKDM4E | |
| SCHEMBL14252003 | 0.78 | LPAR1 (0.35) | LPAR1LPAR5 | |
| SCHEMBL4364207 | 0.78 | LPAR1 (0.43) | LPAR1LPAR5ALDH1A1MAPTMEN1 | |
| SCHEMBL14252009 | 0.77 | LPAR1 (0.41) | LPAR1LPAR5 | |
| SCHEMBL4020149 | 0.76 | CARM1 (0.41) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL13632815 | 0.72 | LPAR1 (0.40) | LPAR1LPAR5ALDH1A1MEN1KMT2A | |
| SCHEMBL4081699 | 0.72 | SSTR4 (0.45) | LPAR1LPAR5ALDH1A1MEN1KMT2A | |
| SCHEMBL4493480 | 0.70 | F2 (0.39) | LPAR1LPAR5F2F10F7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7618996-B2 | Diaryl ether derivatives and uses thereof | PFIZER INC. (US) | 2009-11-17 | — | — | US | disclosed |
| US-7618996-B2 | Diaryl ether derivatives and uses thereof | PFIZER INC. (US) | 2009-11-17 | — | — | US | disclosed |
| US-20080070887-A1 | Diaryl Ether Derivatives and Uses Thereof | PFIZER INC | 2008-03-20 | — | — | US | disclosed |
| US-20080070887-A1 | Diaryl Ether Derivatives and Uses Thereof | PFIZER INC | 2008-03-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080070887-A1 | Diaryl Ether Derivatives and Uses Thereof | OPRD1, OPRK1, OPRL1 | LPAR1 644/4885LPAR5 1129/4885ALDH1A1 492/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.