Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.34 |
| ▸ | HTR2C | P28335 | 5/20 | 0.33 |
| ▸ | HTR2B | P41595 | 5/20 | 0.33 |
| ▸ | HTR2A | P28223 | 4/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.31 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.30 |
| ▸ | HTR1B | P28222 | 1/20 | 0.30 |
| ▸ | HTR6 | P50406 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2857789 | 0.81 | P2RX3 (0.36) | TRPV1P2RX3 | |
| SCHEMBL997142 | 0.75 | P2RX3 (0.56) | P2RX3 | |
| SCHEMBL997141 | 0.75 | P2RX3 (0.56) | P2RX3 | |
| SCHEMBL8251107 | 0.74 | TRPV1 (0.52) | TRPV1 | |
| SCHEMBL4348289 | 0.73 | P2RX3 (0.64) | P2RX3 | |
| SCHEMBL4339725 | 0.72 | TTBK1 (0.51) | HTR2CHTR2B | |
| SCHEMBL2846226 | 0.69 | TRPV1 (0.57) | TRPV1 | |
| SCHEMBL16510169 | 0.68 | HTR2B (0.42) | HTR2CHTR2BHTR2AP2RX3 | |
| SCHEMBL2847843 | 0.67 | TRPV1 (0.40) | TRPV1HTR2CHTR2BHTR2A | |
| SCHEMBL29186336 | 0.67 | PNMT (0.41) | SOS1HTR2CHTR2BHTR2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2136639-A1 | PYRID-2-YL FUSED HETEROCYCLIC COMPOUNDS, AND COMPOSITIONS AND USES THEREOF | Renovis, Inc. (US) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008123963-A1 | PYRID-2-YL FUSED HETEROCYCLIC COMPOUNDS, AND COMPOSITIONS AND USES THEREOF | RENOVIS, INC. (US) | 2008-10-16 | — | — | WO | disclosed |