Sugi Predict

Sugi Predict / Compounds / SCHEMBL4355408

SCHEMBL4355408

SCHEMBL4355408

CC(C)(Br)C(=O)NC(C)(C)C(=O)O

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4C Q9H3R0 1/20 0.42
▸ MAPT P10636 1/20 0.39
▸ ALDH1A1 P00352 1/20 0.35
▸ TSHR P16473 1/20 0.35
▸ AR P10275 1/20 0.33
▸ KDM4E B2RXH2 1/20 0.33
▸ SHMT1 P34896 1/20 0.31
▸ SHMT2 P34897 1/20 0.31
▸ NAALAD2 Q9Y3Q0 1/20 0.30
▸ HDAC3 O15379 1/20 0.30
▸ HDAC4 P56524 1/20 0.30
▸ HDAC1 Q13547 1/20 0.30
▸ HDAC7 Q8WUI4 1/20 0.30
▸ HDAC2 Q92769 1/20 0.30
▸ HDAC10 Q969S8 1/20 0.30
▸ HDAC11 Q96DB2 1/20 0.30
▸ HDAC8 Q9BY41 1/20 0.30
▸ HDAC6 Q9UBN7 1/20 0.30
▸ HDAC9 Q9UKV0 1/20 0.30
▸ HDAC5 Q9UQL6 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14384504 0.85 KDM4C (0.42) KDM4CMAPTALDH1A1TSHRAR
SCHEMBL6704123 0.85 KDM4C (0.42) KDM4CMAPTALDH1A1TSHRAR
SCHEMBL14040406 0.79 KDM4C (0.45) KDM4CMAPTALDH1A1TSHRAR
SCHEMBL10187839 0.76 MEN1 (0.39) MAPTALDH1A1KDM4EL3MBTL1
SCHEMBL11739867 0.75 ALDH1A1 (0.43) KDM4CMAPTALDH1A1TSHRAR
SCHEMBL22855366 0.75 KDM4C (0.42) KDM4CMAPTALDH1A1TSHRAR
SCHEMBL4463196 0.75 KDM4C (0.42) KDM4CMAPTALDH1A1TSHRAR
SCHEMBL30066024 0.75 KDM4C (0.42) KDM4CMAPTALDH1A1TSHRAR
Hydrochloric Acid SCHEMBL4469009 0.73 KDM4C (0.41) KDM4CMAPTALDH1A1TSHRAR
SCHEMBL30265312 0.73 KDM4C (0.41) KDM4CMAPTALDH1A1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2909185-B1 MULTIFUNCTIONAL COUPLING REAGENTS HAVING AN AZLACTONE FUNCTION CENTRE NAT RECH SCIENT (FR) 2016-12-07 — — EP disclosed
US-9453843-B2 Multifunctional coupling reagents having an azlactone function CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2016-09-27 — — US disclosed
US-9453843-B2 Multifunctional coupling reagents having an azlactone function CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2016-09-27 — — US disclosed
US-20150285811-A1 MULTIFUNCTIONAL COUPLING REAGENTS HAVING AN AZLACTONE FUNCTION CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2015-10-08 — — US disclosed
US-20150285811-A1 MULTIFUNCTIONAL COUPLING REAGENTS HAVING AN AZLACTONE FUNCTION CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2015-10-08 — — US disclosed
WO-2014060357-A1 MULTIFUNCTIONAL COUPLING REAGENTS HAVING AN AZLACTONE FUNCTION CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) 2014-04-24 — — WO disclosed
US-7557177-B2 Ring-opened azlactone initiators for atom transfer radical polymerization 3M INNOVATIVE PROPERTIES COMPANY (US) 2009-07-07 — — US disclosed
EP-1569966-B1 RING-OPENED AZLACTONE INITIATORS FOR ATOM TRANSFER RADICAL POLYMERIZATION 3M INNOVATIVE PROPERTIES CO (US) 2008-05-28 — — EP disclosed
US-20080027210-A1 RING-OPENED AZLACTONE INITIATORS FOR ATOM TRANSFER RADICAL POLYMERIZATION 3M INNOVATIVE PROPERTIES COMPANY 2008-01-31 — — US disclosed
US-7294742-B2 Ring-opened azlactone initiators for atom transfer radical polymerization 3M INNOVATIVE PROPERTIES COMPANY (US) 2007-11-13 — — US disclosed
US-6969749-B2 Azlactone initiators for atom transfer radical polymerization 3M INNOVATIVE PROPERTIES COMPANY (US) 2005-11-29 — — US disclosed
EP-1569966-A1 RING-OPENED AZLACTONE INITIATORS FOR ATOM TRANSFER RADICAL POLYMERIZATION 3M Innovative Properties Company (US) 2005-09-07 — — EP disclosed
EP-1569967-A1 AZLACTONE INITIATORS FOR ATOM TRANSFER RADICAL POLYMERIZATION 3M Innovative Properties Company (US) 2005-09-07 — — EP disclosed
US-20050159569-A1 Ring-opened azlactone initiators for atom transfer radical polymerization 3M INNOVATIVE PROPERTIES COMPANY 2005-07-21 — — US disclosed
US-6894133-B2 Azlactone initiators for atom transfer radical polymerization 3M INNOVATIVE PROPERTIES COMPANY (US) 2005-05-17 — — US disclosed
US-20050065300-A1 Azlactone initiators for atom transfer radical polymerization 3M INNOVATIVE PROPERTIES COMPANY 2005-03-24 — — US disclosed
WO-2004052944-A1 RING-OPENED AZLACTONE INITIATORS FOR ATOM TRANSFER RADICAL POLYMERIZATION 3M INNOVATIVE PROPERTIES COMPANY (US) 2004-06-24 — — WO disclosed
WO-2004052943-A1 AZLACTONE INITIATORS FOR ATOM TRANSFER RADICAL POLYMERIZATION 3M INNOVATIVE PROPERTIES COMPANY (US) 2004-06-24 — — WO disclosed
US-20040116633-A1 Ring-opened azlactone initiators for atom transfer radical polymerization 3M INNOVATIVE PROPERTIES COMPANY 2004-06-17 — — US disclosed
US-20040116616-A1 Azlactone initiators for atom transfer radical polymerization 3M INNOVATIVE PROPERTIES COMPANY 2004-06-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150285811-A1 MULTIFUNCTIONAL COUPLING REAGENTS HAVING AN AZLACTONE FUNCTION CYP17A1, KLK3, BCR KDM4C 2172/4885MAPT 4797/4885ALDH1A1 511/4885
US-20050159569-A1 Ring-opened azlactone initiators for atom transfer radical polymerization TTL, TERT, AZI2 KDM4C 2189/4885MAPT 1305/4885ALDH1A1 695/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.