SCHEMBL4463196

SCHEMBL4463196

CC(C)(NC(=O)C(F)(F)F)C(=O)O

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4C Q9H3R0 1/20 0.42
CA2 P00918 2/20 0.42
AR P10275 1/20 0.37
ALDH1A1 P00352 2/20 0.36
POLB P06746 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
TSHR P16473 1/20 0.35
MEN1 O00255 1/20 0.34
KMT2A Q03164 1/20 0.34
EPHX1 P07099 1/20 0.33
EGLN1 Q9GZT9 1/20 0.32
EGLN3 Q9H6Z9 1/20 0.32
MAPT P10636 1/20 0.31
CA3 P07451 2/20 0.31
CA5A P35218 2/20 0.31
CA5B Q9Y2D0 2/20 0.31
CA12 O43570 1/20 0.31
CA4 P22748 1/20 0.31
CA6 P23280 1/20 0.31
CA7 P43166 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL4469009 0.98 KDM4C (0.41) KDM4CCA2ARALDH1A1POLB
SCHEMBL14040406 0.79 KDM4C (0.45) KDM4CARALDH1A1POLBSMN1; SMN2
SCHEMBL4469005 0.78 CA2 (0.40) CA2ALDH1A1POLBSMN1; SMN2MEN1
SCHEMBL6462033 0.76 CA2 (0.39) CA2ALDH1A1POLBSMN1; SMN2TSHR
SCHEMBL6462028 0.76 CA2 (0.39) CA2ALDH1A1POLBSMN1; SMN2TSHR
SCHEMBL2757992 0.76 CA2 (0.48) CA2ALDH1A1POLBSMN1; SMN2MEN1
SCHEMBL14384504 0.75 KDM4C (0.42) KDM4CARALDH1A1TSHRMAPT
SCHEMBL22855366 0.75 KDM4C (0.42) KDM4CARALDH1A1TSHRMAPT
SCHEMBL11739867 0.75 ALDH1A1 (0.43) KDM4CARALDH1A1TSHRMEN1
SCHEMBL30066024 0.75 KDM4C (0.42) KDM4CARALDH1A1TSHRMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 41 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250353875-A1 PEPTIDE SYNTHESIS METHOD FOR SUPPRESSING DEFECT CAUSED BY DIKETOPIPERAZINE FORMATION CHUGAI PHARMACEUTICAL CO LTD (JP) 2025-11-20 US disclosed
US-12404299-B2 Method for producing peptide compound comprising highly sterically hindered amino acid CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2025-09-02 US disclosed
US-12371454-B2 Cyclic peptide compound having Kras inhibitory action CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2025-07-29 US disclosed
EP-4509517-A1 PEPTIDE SYNTHESIS METHOD FOR SUPPRESSING DEFECT CAUSED BY DIKETOPIPERAZINE FORMATION CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2025-02-19 EP disclosed
CN-114630835-B Process for the preparation of peptide compounds comprising sterically bulky amino acids 中外制药株式会社 2025-02-11 CN disclosed
US-20240400617-A1 CYCLIC PEPTIDE COMPOUND HAVING KRAS INHIBITORY ACTION CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2024-12-05 US disclosed
US-20240148821-A1 PHARMACEUTICAL USE OF CYCLIC PEPTIDE COMPOUND CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2024-05-09 US disclosed
EP-4316503-A1 PHARMACEUTICAL USE OF CYCLIC PEPTIDE COMPOUND CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2024-02-07 EP disclosed
US-20230391818-A1 PEPTIDE SYNTHESIS METHOD FOR SUPPRESSING DEFECT CAUSED BY DIKETOPIPERAZINE FORMATION CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2023-12-07 US disclosed
WO-2023214577-A1 PEPTIDE SYNTHESIS METHOD FOR SUPPRESSING DEFECT CAUSED BY DIKETOPIPERAZINE FORMATION 中外製薬株式会社 2023-11-09 WO disclosed
EP-0743857-A4 METHOD OF MAKING POLYMERS HAVING SPECIFIC PROPERTIES ARQULE INC (US) 1998-07-15 EP disclosed
EP-0737232-A4 MODULAR DESIGN AND SYNTHESIS OF AMINIMIDE CONTAINING MOLECULES ARQULE INC (US) 1997-11-26 EP disclosed
EP-0743857-A1 METHOD OF MAKING POLYMERS HAVING SPECIFIC PROPERTIES ARQULE, INC. (US) 1996-11-27 EP disclosed
EP-0737232-A1 MODULAR DESIGN AND SYNTHESIS OF AMINIMIDE CONTAINING MOLECULES ARQULE, INC. (US) 1996-10-16 EP disclosed
US-5538988-A CARDIOVASCULAR DISORDERS AND DOPAMINE HYDROLASE ENZYME INHIBITORS SYNTEX (U.S.A.) INC. 1996-07-23 US disclosed
WO-1995018627-A1 METHOD OF MAKING POLYMERS HAVING SPECIFIC PROPERTIES ARQULE, INC. (US) 1995-07-13 WO disclosed
WO-1995018186-A1 MODULAR DESIGN AND SYNTHESIS OF AMINIMIDE CONTAINING MOLECULES ARQULE PARTNERS, L.P. (US) 1995-07-06 WO disclosed
EP-0015773-B1 N-(6-((ACYLAMINOACYLAMINO OR AMINOACYLAMINO)PHENYL) 1,2-DIHYDRO-2-OXONICOTINYL)PENICILLIN COMPOUNDS, PROCESSES FOR THEIR PRODUCTION AND COMPOSITIONS CONTAINING THEM WARNER-LAMBERT COMPANY (US) 1983-07-20 EP disclosed
US-4278681-A N-/6-//ACYLAMINOACYLAMINO OR AMINOACYLAMINO/PHENYL/-1,2-DIHYDRO-2-OXONICOTINYL/PENICILLINS WARNER-LAMBERT CO. (US) 1981-07-14 US disclosed
EP-0015773-A2 N-(6-((acylaminoacylamino or aminoacylamino)phenyl) 1,2-dihydro-2-oxonicotinyl)penicillin compounds, processes for their production and compositions containing them WARNER-LAMBERT COMPANY (US) 1980-09-17 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240400617-A1 CYCLIC PEPTIDE COMPOUND HAVING KRAS INHIBITORY ACTION KRAS, NRAS, HRAS KDM4C 4445/4885CA2 1953/4885AR 4219/4885
US-20240148821-A1 PHARMACEUTICAL USE OF CYCLIC PEPTIDE COMPOUND VIP, IAPP, KRAS KDM4C 4755/4885CA2 985/4885AR 3023/4885
US-20230391818-A1 PEPTIDE SYNTHESIS METHOD FOR SUPPRESSING DEFECT CAUSED BY DIKETOPIPERAZINE FORMATION VIP, DNPEP, NPPA KDM4C 2977/4885CA2 2955/4885AR 3598/4885
US-12404299-B2 Method for producing peptide compound comprising highly sterically hindered amino acid DNPEP, VIP, NPEPPS KDM4C 4665/4885CA2 3659/4885AR 1681/4885
US-20250353875-A1 PEPTIDE SYNTHESIS METHOD FOR SUPPRESSING DEFECT CAUSED BY DIKETOPIPERAZINE FORMATION VIP, NPPA, DNPEP KDM4C 2693/4885CA2 2848/4885AR 3660/4885
US-12371454-B2 Cyclic peptide compound having Kras inhibitory action KRAS, NRAS, HRAS KDM4C 4445/4885CA2 1953/4885AR 4219/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.