Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2588666 | 0.80 | — | — | |
| SCHEMBL8377028 | 0.80 | — | — | |
| SCHEMBL575570 | 0.80 | — | — | |
| SCHEMBL4953927 | 0.71 | POLB (0.41) | POLBTRPM8TSHR | |
| Bicarbonate SCHEMBL10767839 | 0.70 | EPHX1 (0.39) | POLBTRPM8 | |
| Methoxymethane SCHEMBL5904835 | 0.70 | TRPA1 (0.34) | POLBTRPM8 | |
| SCHEMBL28457899 | 0.70 | POLB (0.40) | POLBTRPM8TSHR | |
| SCHEMBL30039168 | 0.70 | POLB (0.40) | POLBTRPM8TSHR | |
| SCHEMBL15974641 | 0.70 | POLB (0.40) | POLBTRPM8TSHR | |
| SCHEMBL18783118 | 0.70 | TRPM8 (0.36) | TRPM8TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8343465-B2 | Cooling cosmetic or dermatological preparations comprising (1R,2S,5R)-2-isopropyl-5-methyl-N-(2-(pyridin-2-yl)ethyl)-cyclohexane carboxamide and/or (1R,2S,5R)-N-(4-cyanomethyl-phenyl)-2-isopropyl-5-methylcyclohexane carboxamide for reducing skin reddening | BEIERSDORF AG (DE) | 2013-01-01 | — | — | US | claimed |
| US-20090311206-A1 | COOLING COSMETIC OR DERMATOLOGICAL PREPARATIONS COMPRISING (1R,2S,5R)-2-ISOPROPYL-5-METHYL-N-(2-(PYRIDIN-2-YL)ETHYL)-CYCLOHEXANE CARBOXAMIDE AND/OR (1R,2S,5R)-N-(4-CYANOMETHYL-PHENYL)-2-ISOPROPYL-5-METHYLCYCLOHEXANE CARBOXAMIDE FOR REDUCING SKIN REDDENING | BEIERSDORF AG (DE) | 2009-12-17 | — | — | US | claimed |
| US-8343465-B2 | Cooling cosmetic or dermatological preparations comprising (1R,2S,5R)-2-isopropyl-5-methyl-N-(2-(pyridin-2-yl)ethyl)-cyclohexane carboxamide and/or (1R,2S,5R)-N-(4-cyanomethyl-phenyl)-2-isopropyl-5-methylcyclohexane carboxamide for reducing skin reddening | BEIERSDORF AG (DE) | 2013-01-01 | — | — | US | disclosed |
| US-20090311206-A1 | COOLING COSMETIC OR DERMATOLOGICAL PREPARATIONS COMPRISING (1R,2S,5R)-2-ISOPROPYL-5-METHYL-N-(2-(PYRIDIN-2-YL)ETHYL)-CYCLOHEXANE CARBOXAMIDE AND/OR (1R,2S,5R)-N-(4-CYANOMETHYL-PHENYL)-2-ISOPROPYL-5-METHYLCYCLOHEXANE CARBOXAMIDE FOR REDUCING SKIN REDDENING | BEIERSDORF AG (DE) | 2009-12-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090311206-A1 | COOLING COSMETIC OR DERMATOLOGICAL PREPARATIONS COMPRISING (1R,2S,5R)-2-ISOPROPYL-5-METHYL-N-(2-(PYRIDIN-2-YL)ETHYL)-CYCLOHEXANE CARBOXAMIDE AND/OR (1R,2S,5R)-N-(4-CYANOMETHYL-PHENYL)-2-ISOPROPYL-5-METHYLCYCLOHEXANE CARBOXAMIDE FOR REDUCING SKIN REDDENING | CUTA, MC5R, MC1R | POLB 1497/4885TRPM8 138/4885TSHR 2345/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.