Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 9/20 | 0.34 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5077546 | 0.90 | KDM4E (0.45) | KDM4ECYP3A4CYP2C19HIF1AALDH1A1 | |
| SCHEMBL4356848 | 0.88 | KDM4E (0.43) | KDM4ECYP3A4CYP2C19HIF1AALDH1A1 | |
| SCHEMBL3133511 | 0.83 | THRB (0.51) | KDM4ECYP3A4CYP2C19HIF1AHPGD | |
| SCHEMBL3140761 | 0.83 | MCHR1 (0.38) | KDM4ECYP3A4CYP2C19HIF1ACYP1A2 | |
| SCHEMBL3145767 | 0.82 | THRA (0.37) | KDM4ECYP3A4CYP2C19HIF1AALDH1A1 | |
| SCHEMBL5077547 | 0.78 | KDM4E (0.45) | KDM4ECYP3A4CYP2C19HIF1AALDH1A1 | |
| SCHEMBL3131792 | 0.73 | THRB (0.53) | KDM4ECYP3A4CYP2C19HIF1AALDH1A1 | |
| SCHEMBL3141802 | 0.73 | MAPT (0.38) | KDM4ECYP3A4CYP2C19HIF1AALDH1A1 | |
| SCHEMBL5073565 | 0.68 | KDM4E (0.38) | KDM4EALDH1A1HPGDHSD17B10PDE10A | |
| SCHEMBL13777688 | 0.67 | KDM4E (0.62) | KDM4EALDH1A1HPGDCYP1A2PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009080835-A1 | THYROMIMETRIC COMPOUNDS IN TREATMENT OF DISEASE RELATED TO SONIC HEDGEHOG SIGNALLING | KARO BIO AB (SE) | 2009-07-02 | — | — | WO | claimed |