Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | RAD52 | P43351 | 2/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4356847 | 0.90 | KDM4E (0.43) | KDM4ECYP2C19CYP3A4HIF1AALDH1A1 | |
| SCHEMBL5077547 | 0.88 | KDM4E (0.45) | KDM4ECYP2C19CYP3A4HIF1AALDH1A1 | |
| SCHEMBL3131792 | 0.82 | THRB (0.53) | KDM4ECYP2C19CYP3A4HIF1AALDH1A1 | |
| SCHEMBL3141802 | 0.81 | MAPT (0.38) | KDM4ECYP2C19CYP3A4HIF1AALDH1A1 | |
| SCHEMBL4356848 | 0.78 | KDM4E (0.43) | KDM4ECYP2C19CYP3A4HIF1AALDH1A1 | |
| SCHEMBL3133511 | 0.74 | THRB (0.51) | KDM4ECYP2C19CYP3A4HIF1AHPGD | |
| SCHEMBL3145767 | 0.73 | THRA (0.37) | KDM4ECYP2C19CYP3A4HIF1AALDH1A1 | |
| SCHEMBL10226046 | 0.68 | KDM4E (0.44) | KDM4ECYP2C19CYP3A4HIF1AALDH1A1 | |
| SCHEMBL3969032 | 0.65 | CYP1A2 (0.60) | KDM4EALDH1A1CYP1A2HPGDKMT2A | |
| SCHEMBL21848461 | 0.65 | KDM4E (0.44) | KDM4ECYP2C19CYP3A4HIF1AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899309-A1 | HETEROCYCLIC COMPOUNDS AS AGONISTS FOR THE THYROID RECEPTOR | KARO BIO AB (SE) | 2008-03-19 | — | — | EP | disclosed |
| WO-2007003419-A1 | HETEROCYCLIC COMPOUNDS AS AGONISTS FOR THE THYROID RECEPTOR | KARO BIO AB (SE) | 2007-01-11 | — | — | WO | disclosed |