Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN3 | Q9H6Z9 | 3/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.42 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.38 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4364331 | 0.88 | HIF1A (0.43) | EGLN3HIF1AEGLN1HTTMEN1 | |
| SCHEMBL4356163 | 0.87 | EGLN3 (0.42) | EGLN3HIF1AEGLN1MEN1KMT2A | |
| SCHEMBL3846837 | 0.85 | EGLN3 (0.50) | EGLN3HIF1AEGLN1TP53MDM2 | |
| SCHEMBL4371854 | 0.83 | EGLN3 (0.54) | EGLN3HIF1AEGLN1MAPTLMNA | |
| SCHEMBL4362443 | 0.82 | EGLN3 (0.52) | EGLN3EGLN1 | |
| SCHEMBL4356985 | 0.82 | EGLN3 (0.43) | EGLN3HIF1AEGLN1HTTTSHR | |
| SCHEMBL4365040 | 0.82 | EGLN3 (0.48) | EGLN3HIF1AEGLN1SLC13A5 | |
| SCHEMBL4359892 | 0.81 | EGLN3 (0.59) | EGLN3EGLN1 | |
| SCHEMBL4359785 | 0.80 | EGLN3 (0.68) | EGLN3EGLN1MAPTL3MBTL1KMT2A | |
| SCHEMBL4359069 | 0.80 | EGLN3 (0.51) | EGLN3HIF1AEGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2124565-A2 | N-SUBSTITUTED GLYCINE DERIVATIVES: HYDROXYLASE INHIBITORS | Smithkline Beecham Corporation (US) | 2009-12-02 | — | — | EP | claimed |
| WO-2008089052-A2 | N-SUBSTITUTED GLYCINE DERIVATIVES: HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-24 | — | — | WO | claimed |