Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCN4 | Q9Y3Q4 | 4/20 | 0.63 |
| ▸ | HCN1 | O60741 | 5/20 | 0.54 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.54 |
| ▸ | TP53 | P04637 | 3/20 | 0.52 |
| ▸ | IL1B | P01584 | 3/20 | 0.50 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.49 |
| ▸ | SLC6A9 | P48067 | 4/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3688404 | 1.00 | HCN4 (0.63) | HCN4HCN1P2RX7TP53IL1B | |
| SCHEMBL4351759 | 0.97 | HCN4 (0.60) | HCN4HCN1P2RX7TP53IL1B | |
| SCHEMBL4537785 | 0.92 | HCN4 (0.52) | HCN4HCN1P2RX7IL1BSLC6A9 | |
| SCHEMBL13706846 | 0.92 | HCN4 (0.59) | HCN4HCN1P2RX7TP53IL1B | |
| SCHEMBL4537218 | 0.92 | HCN4 (0.54) | HCN4HCN1P2RX7IL1BSLC6A9 | |
| SCHEMBL4530146 | 0.92 | HCN4 (0.54) | HCN4HCN1P2RX7IL1BSLC6A9 | |
| SCHEMBL13706814 | 0.91 | HCN4 (0.51) | HCN4HCN1P2RX7TP53IL1B | |
| SCHEMBL4350608 | 0.91 | HCN4 (0.55) | HCN4HCN1P2RX7IL1BSLC6A9 | |
| SCHEMBL4361081 | 0.91 | HCN4 (0.55) | HCN4HCN1P2RX7IL1BSLC6A9 | |
| SCHEMBL4355954 | 0.90 | HCN1 (0.62) | HCN4HCN1P2RX7TP53OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009108551-A2 | HETEROARYL AMIDE ANALOGUES | H. LUNDBECK A/S (DK) | 2009-09-03 | — | — | WO | claimed |
| WO-2009108551-A2 | HETEROARYL AMIDE ANALOGUES | H. LUNDBECK A/S (DK) | 2009-09-03 | — | — | WO | disclosed |