Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCN1 | O60741 | 6/20 | 0.62 |
| ▸ | HCN4 | Q9Y3Q4 | 6/20 | 0.54 |
| ▸ | THRB | P10828 | 3/20 | 0.54 |
| ▸ | TP53 | P04637 | 4/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4535037 | 0.91 | HCN4 (0.55) | HCN1HCN4THRBTP53ALDH1A1 | |
| SCHEMBL4364182 | 0.91 | HCN4 (0.56) | HCN1HCN4THRBTP53ALDH1A1 | |
| SCHEMBL3688404 | 0.90 | HCN4 (0.63) | HCN1HCN4THRBTP53OPRM1 | |
| SCHEMBL4357339 | 0.90 | HCN4 (0.63) | HCN1HCN4THRBTP53OPRM1 | |
| SCHEMBL4355970 | 0.90 | HCN1 (0.54) | HCN1HCN4THRBTP53OPRM1 | |
| SCHEMBL4351759 | 0.88 | HCN4 (0.60) | HCN1HCN4THRBTP53OPRM1 | |
| SCHEMBL13706853 | 0.88 | HCN1 (0.60) | HCN1HCN4THRBTP53OPRM1 | |
| SCHEMBL13706779 | 0.85 | HCN1 (0.57) | HCN1HCN4THRBTP53OPRM1 | |
| SCHEMBL13706601 | 0.85 | HCN1 (0.44) | HCN1HCN4THRBTP53ALDH1A1 | |
| SCHEMBL4540375 | 0.85 | HCN1 (0.44) | HCN1HCN4THRBTP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009108551-A2 | HETEROARYL AMIDE ANALOGUES | H. LUNDBECK A/S (DK) | 2009-09-03 | — | — | WO | claimed |
| WO-2009108551-A2 | HETEROARYL AMIDE ANALOGUES | H. LUNDBECK A/S (DK) | 2009-09-03 | — | — | WO | disclosed |