Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.58 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.51 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 2/20 | 0.49 |
| ▸ | JAK1 | P23458 | 1/20 | 0.48 |
| ▸ | TYK2 | P29597 | 1/20 | 0.48 |
| ▸ | JAK3 | P52333 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | F10 | P00742 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4358006 | 0.91 | IRAK4 (0.61) | IRAK4CHEK1TLR7ATMKDM4E | |
| SCHEMBL13818341 | 0.88 | IRAK4 (0.55) | IRAK4CHEK1JAK2JAK3BTK | |
| SCHEMBL4349506 | 0.88 | IRAK4 (0.61) | IRAK4CHEK1MEN1LMNAMAPT | |
| SCHEMBL13818665 | 0.82 | IRAK4 (0.50) | IRAK4CHEK1SMN1; SMN2F10NPC1 | |
| SCHEMBL13818373 | 0.82 | IRAK4 (0.53) | IRAK4CHEK1JAK2JAK3BTK | |
| SCHEMBL13818544 | 0.79 | IRAK4 (0.56) | IRAK4CHEK1JAK2JAK3MAPT | |
| SCHEMBL4357829 | 0.77 | IRAK4 (0.75) | IRAK4CHEK1TLR7ATMNPC1 | |
| SCHEMBL4361829 | 0.77 | IRAK4 (0.61) | IRAK4CHEK1MEN1LMNAMAPT | |
| SCHEMBL2080467 | 0.74 | CHEK1 (0.55) | IRAK4CHEK1ATMKDM4EMEN1 | |
| SCHEMBL2140489 | 0.73 | NPC1 (0.77) | IRAK4CHEK1TLR7ATMGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2070916-A1 | 2-Arylthiazol-4-carboxylic acid derivatives, their manufacture and use as medicine | Bayer Schering Pharma Aktiengesellschaft (DE) | 2009-06-17 | — | — | EP | claimed |
| EP-2070916-A1 | 2-Arylthiazol-4-carboxylic acid derivatives, their manufacture and use as medicine | Bayer Schering Pharma Aktiengesellschaft (DE) | 2009-06-17 | — | — | EP | disclosed |
| EP-2070916-A1 | 2-Arylthiazol-4-carboxylic acid derivatives, their manufacture and use as medicine | Bayer Schering Pharma Aktiengesellschaft (DE) | 2009-06-17 | — | — | EP | disclosed |