SCHEMBL4357900

SCHEMBL4357900

Nc1nc(=O)c2ncn([C@@H]3O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)OP(=O)(O)OC[C@H]4O[C@@H](n5cnc6c(=O)nc(N)[nH]c65)[C@H](O)[C@@H]4O)[C@@H](O)[C@H]3O)c2[nH]1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TGM2 P21980 1/20 0.65
P2RX3 P56373 3/20 0.65
P2RY1 P47900 8/20 0.64
P2RY2 P41231 3/20 0.64
P2RX1 P51575 2/20 0.64
P2RX4 Q99571 2/20 0.64
SRC P12931 1/20 0.64
P2RX2 Q9UBL9 1/20 0.64
ALDH1A1 P00352 1/20 0.64
SMN1; SMN2 Q16637 1/20 0.64
KRAS P01116 2/20 0.61
FUT5 Q11128 1/20 0.60
NT5E P21589 1/20 0.60
MACROD2 A1Z1Q3 1/20 0.60
SIRT6 Q8N6T7 1/20 0.60
MACROD1 Q9BQ69 1/20 0.60
TRPM2 O94759 1/20 0.60
P2RY6 Q15077 2/20 0.58
P2RY11 Q96G91 2/20 0.58
ENPP1 P22413 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18661219 1.00 TGM2 (0.65) TGM2P2RX3P2RY1P2RY2P2RX1
SCHEMBL4362564 1.00 TGM2 (0.65) TGM2P2RX3P2RY1P2RY2P2RX1
Gtp SCHEMBL4368666 0.97 TGM2 (0.62) TGM2P2RX3P2RY1P2RY2P2RX1
Gtp SCHEMBL4362801 0.97 TGM2 (0.62) TGM2P2RX3P2RY1P2RY2P2RX1
Guanosine Triphosphate SCHEMBL44409 0.97 TGM2 (0.62) TGM2P2RX3P2RY1P2RY2P2RX1
Guanosine Triphosphate SCHEMBL4362831 0.97 TGM2 (0.62) TGM2P2RX3P2RY1P2RY2P2RX1
SCHEMBL2341432 0.96 P2RY1 (0.62) TGM2P2RX3P2RY1P2RY2P2RX1
Guanosine Triphosphate SCHEMBL20266272 0.96 TGM2 (0.62) TGM2P2RX3P2RY1P2RY2P2RX1
SCHEMBL31145699 0.95 P2RY1 (0.61) TGM2P2RX3P2RY1P2RY2P2RX1
SCHEMBL4366717 0.95 TGM2 (0.62) TGM2P2RX3P2RY1P2RY2P2RX1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150366777-A1 COMBINATION OF SKIN PROTECTION AGAINST DAMAGES CAUSED BY INFRARED RADIATION HYPERMARCAS S.A. (BR) 2015-12-24 US claimed
US-20260021027-A1 POLYPEPTIDE COSMETIC COMPOSITIONS ELC MANAGEMENT LLC (US) 2026-01-22 US disclosed
CN-114795996-B Composition containing nucleoside components and application thereof 广东先强药业有限公司 2023-08-29 CN disclosed
CN-114795996-A Composition containing nucleoside components and application thereof 广东先强药业有限公司 2022-07-29 CN disclosed
US-20150366777-A1 COMBINATION OF SKIN PROTECTION AGAINST DAMAGES CAUSED BY INFRARED RADIATION HYPERMARCAS S.A. (BR) 2015-12-24 US disclosed
US-20090186358-A1 Pathway Analysis of Cell Culture Phenotypes and Uses Thereof WYETH (US) 2009-07-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260021027-A1 POLYPEPTIDE COSMETIC COMPOSITIONS CUTA, SPPL2B, SPPL2A TGM2 177/4885P2RX3 2891/4885P2RY1 1799/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.