SCHEMBL4359124

SCHEMBL4359124

O=P(O)(O)C(N1CCCN(C(P(=O)(O)O)P(=O)(O)O)CCCN(C(P(=O)(O)O)P(=O)(O)OCCOCCOCCOCCO)CCC1)P(=O)(O)O

nearest known ligand 0.49

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
FDPS P14324 3/20 0.49
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
TSHR P16473 1/20 0.30
MAPK1 P28482 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8339034 0.77 ANPEP (0.38) FDPSMEN1KMT2A
SCHEMBL2203676 0.74 FDPS (0.85) FDPS
SCHEMBL6667933 0.72 FDPS (0.42) FDPSMEN1KMT2A
SCHEMBL6668133 0.70 CYP3A4 (0.42) FDPSTSHR
SCHEMBL5075884 0.68 FDPS (0.45) FDPSTSHR
SCHEMBL6670360 0.68 FDPS (0.45) FDPSTSHR
N-(Hexamethyleneimino)Methylenebisphosphonic Acid SCHEMBL12309768 0.68 FDPS (1.00) FDPSMEN1KMT2ATSHR
SCHEMBL2472093 0.68 FDPS (1.00) FDPSMEN1KMT2ATSHR
Ammonia Solution, Strong SCHEMBL7721218 0.67 MEN1 (0.37) MEN1KMT2ATSHRMAPK1
SCHEMBL125343 0.66 MEN1 (0.55) MEN1KMT2ATSHRMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2067490-A1 Chelating agent derivatives and compositions comprising the same for use in imaging methods Koninklijke Philips Electronics N.V. (NL) 2009-06-10 EP claimed
EP-1487334-A4 PARAMAGNETIC PARTICLES THAT PROVIDE IMPROVED RELAXIVITY BARNES JEWISH HOSPITAL (US) 2006-10-25 EP claimed
JP-2005521704-A 2005-07-21 JP claimed
US-6869591-B2 Paramagnetic particles that provide improved relaxivity BARNES-JEWISH HOSPITAL (US) 2005-03-22 US claimed
EP-1487334-A1 PARAMAGNETIC PARTICLES THAT PROVIDE IMPROVED RELAXIVITY Barnes-Jewish Hospital (US) 2004-12-22 EP claimed
US-20030215392-A1 Paramagnetic particles that provide improved relaxivity KEREOS, INC. 2003-11-20 US claimed
WO-2003082105-A1 PARAMAGNETIC PARTICLES THAT PROVIDE IMPROVED RELAXIVITY BARNES-JEWISH HOSPITAL (US) 2003-10-09 WO claimed
US-20030185760-A1 Paramagnetic particles that provide improved relaxivity KEREOS, INC. 2003-10-02 US claimed
WO-2021048417-A1 COMBINATION THERAPIES COMPRISING DASATINIB FOR THE TREATMENT OF CHOLANGIOCARCINOMA SEALD AS (NO) 2021-03-18 WO disclosed
WO-2018029624-A1 SUBCUTANEOUS FORMULATIONS OF PALONOSETRON LEIUTIS PHARMACEUTICALS PVT, LTD. (IN) 2018-02-15 WO disclosed
WO-2016166653-A1 STABLE LIQUID PHARMACEUTICAL COMPOSITIONS OF BORTEZOMIB LEIUTIS PHARMACEUTICALS PVT LTD (IN) 2016-10-20 WO disclosed
WO-2009072074-A1 CHELATING AGENT DERIVATIVES AND COMPOSITIONS COMPRISING THE SAME FOR USE IN IMAGING METHODS KONINKLIJKE PHILIPS ELECTRONICS N.V. (NL) 2009-06-11 WO disclosed
EP-2067490-A1 Chelating agent derivatives and compositions comprising the same for use in imaging methods Koninklijke Philips Electronics N.V. (NL) 2009-06-10 EP disclosed